7190580
IL-17A Monoclonal Antibody (20B4.G10.F5), Rockland™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Mouse IL-17A
Concentration
2.94 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias
BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; IL17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; Interleukin-17A; LOC100339322; R-IL-17-A
Gene Symbols
IL17A
Isotype
IgG2a κ
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
IL17A
Clone
20B4.G10.F5
Applications
ELISA, Flow Cytometry, Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q62386
Gene ID (Entrez)
16171
Immunogen
This Mouse IL-17A monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse IL-17A protein (produced in E.coli) followed by hybridoma development.
Primary or Secondary
Primary
Product Type
Antibody
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This monoclonal antibody is purified by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above
- This antibody is specific for mouse IL-17A protein
- Cross-reactivity with IL-17A from other sources has not been determined
- Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection
- IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217)
- High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts
- In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2
- In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils
- Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor
- IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
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Antigen: Mouse IL-17A
Concentration: 2.94 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; IL17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; Interleukin-17A; LOC100339322; R-IL-17-A
Gene Symbols: IL17A
Isotype: IgG2a κ
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: IL17A
Clone: 20B4.G10.F5
Applications: ELISA, Flow Cytometry, Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q62386
Gene ID (Entrez): 16171
Immunogen: This Mouse IL-17A monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse IL-17A protein (produced in E.coli) followed by hybridoma development.
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
Mouse IL-17A
Concentration:
2.94 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; IL17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; Interleukin-17A; LOC100339322; R-IL-17-A
Gene Symbols:
IL17A
Isotype:
IgG2a κ
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
IL17A
Clone:
20B4.G10.F5
Applications:
ELISA, Flow Cytometry, Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q62386
Gene ID (Entrez):
16171
Immunogen:
This Mouse IL-17A monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse IL-17A protein (produced in E.coli) followed by hybridoma development.
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: TBK1
Concentration: 1 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: 1200008B05Rik; AI462036; AW048562; BOS_5439; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1
Gene Symbols: TBK1
Isotype: __
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: TBK1
Clone: __
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: Q9UHD2, Q9WUN2
Gene ID (Entrez): 29110, 56480
Immunogen: __
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
TBK1
Concentration:
1 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
1200008B05Rik; AI462036; AW048562; BOS_5439; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1
Gene Symbols:
TBK1
Isotype:
__
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
TBK1
Clone:
__
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
Q9UHD2, Q9WUN2
Gene ID (Entrez):
29110, 56480
Immunogen:
__
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: ABCB8
Concentration: 80 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: 4833412N02Rik; AA409895; ABC transporter 8; Abcb8; ATP binding cassette subfamily B member 8; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, subfamily B (MDR/TAP), member 8; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette, sub-family B, member 8; BOS_4761; EST328128; hypothetical protein LOC548340; MABC1; M-ABC1; mitochondrial ABC protein; Mitochondrial ATP-binding cassette 1; zgc:113037
Gene Symbols: ABCB8
Isotype: __
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: ABCB8
Clone: __
Applications: ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q9NUT2
Gene ID (Entrez): 11194
Immunogen: ABCB8 was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a internal portion of human ABCB8.
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
ABCB8
Concentration:
80 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
4833412N02Rik; AA409895; ABC transporter 8; Abcb8; ATP binding cassette subfamily B member 8; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, subfamily B (MDR/TAP), member 8; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette, sub-family B, member 8; BOS_4761; EST328128; hypothetical protein LOC548340; MABC1; M-ABC1; mitochondrial ABC protein; Mitochondrial ATP-binding cassette 1; zgc:113037
Gene Symbols:
ABCB8
Isotype:
__
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
ABCB8
Clone:
__
Applications:
ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q9NUT2
Gene ID (Entrez):
11194
Immunogen:
ABCB8 was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a internal portion of human ABCB8.
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: Phospho-MEK1/2 (Ser222, Ser226)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: CFC3; dual specificity mitogen activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2); MAP kinase/Erk kinase 1; MAP2K1; map2k1.L; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; Mek1; MEK2; mek-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1 L homeolog; MKK (Thr292); MKK (Thr386); MKK1; MKK2; MP2K1; Prkmk1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); XELAEV_18018447mg
Gene Symbols: Map2k1
Isotype: IgG1 λ
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: Map2k1
Clone: 17C9.E1.H2.D7.H7.D5
Applications: ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human, Mouse, Rat
Gene Accession No.: P31938, Q01986, Q02750
Gene ID (Entrez): 170851, 26395, 5604
Immunogen: Anti-MEK1 pS222/MEK2 pS226 Monoclonal Antibody was produced in mice by repeated immunizations with synthetic peptide corresponding to amino acid residues surrounding the S222-226 phosphorylation site conjugated to KLH.
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
Phospho-MEK1/2 (Ser222, Ser226)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
CFC3; dual specificity mitogen activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2); MAP kinase/Erk kinase 1; MAP2K1; map2k1.L; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; Mek1; MEK2; mek-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1 L homeolog; MKK (Thr292); MKK (Thr386); MKK1; MKK2; MP2K1; Prkmk1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); XELAEV_18018447mg
Gene Symbols:
Map2k1
Isotype:
IgG1 λ
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
Map2k1
Clone:
17C9.E1.H2.D7.H7.D5
Applications:
ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human, Mouse, Rat
Gene Accession No.:
P31938, Q01986, Q02750
Gene ID (Entrez):
170851, 26395, 5604
Immunogen:
Anti-MEK1 pS222/MEK2 pS226 Monoclonal Antibody was produced in mice by repeated immunizations with synthetic peptide corresponding to amino acid residues surrounding the S222-226 phosphorylation site conjugated to KLH.
Primary or Secondary:
Primary
Product Type:
Antibody