Phospho-JAM A (Tyr280) Polyclonal Antibody, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• Anti-JAM A pY280 is directed against human JAM A phosphorylated at the tyrosine 280 position
• A BLAST analysis was used to suggest reactivity with this protein from human and feline based on 100% homology for the immunogen sequence
• CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors
• CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail
• The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins
• CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact
• CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin
• CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.