L-Selectin/CD62L Antibody (FMC46) - BSA Free, Novus Biologicals™
Mouse Monoclonal Antibody has been used in 1 publication
Manufacturer: Fischer Scientific
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Antigen
L-Selectin/CD62L
Concentration
1.0 mg/mL
Applications
Immunohistochemistry (Frozen), Immunoprecipitation, Immunohistochemistry, Flow Cytometry
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Bovine, Human, Primate, Canine
Gene Alias
CD62L, CD62L antigen, gp90-MEL, hLHRc, LAM-1, LAM1LECAM1, Leu-8, LEU8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LNHRTQ1, LSEL, L-selectin, Lyam-1, LYAM1CD62 antigen-like family member L, Lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor, PLNHR, selectin L
Gene Symbols
SELL
Isotype
IgG2b
Purification Method
Protein G purified
Test Specificity
NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Clone
FMC46
Dilution
Flow Cytometry 1:50-1:100, Immunohistochemistry 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Gene Accession No.
P14151
Gene ID (Entrez)
6402
Immunogen
PHA stimulated lymphoblasts.
Primary or Secondary
Primary
Content And Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Description
- Description L-Selectin/CD62L Monoclonal specifically detects L-Selectin/CD62L in Human, Bovine, Canine, Primate samples
- It is validated for Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Immunohistochemistry-Frozen.
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Antigen: L-Selectin/CD62L
Concentration: 1.0 mg/mL
Applications: Immunohistochemistry (Frozen), Immunoprecipitation, Immunohistochemistry, Flow Cytometry
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Bovine, Human, Primate, Canine
Gene Alias: CD62L, CD62L antigen, gp90-MEL, hLHRc, LAM-1, LAM1LECAM1, Leu-8, LEU8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LNHRTQ1, LSEL, L-selectin, Lyam-1, LYAM1CD62 antigen-like family member L, Lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor, PLNHR, selectin L
Gene Symbols: SELL
Isotype: IgG2b
Purification Method: Protein G purified
Test Specificity: NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Clone: FMC46
Dilution: Flow Cytometry 1:50-1:100, Immunohistochemistry 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Gene Accession No.: P14151
Gene ID (Entrez): 6402
Immunogen: PHA stimulated lymphoblasts.
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Antigen: J Chain
Concentration: 1.0 mg/mL
Applications: Immunohistochemistry (Frozen), Immunohistochemistry, Western Blot, ELISA, Immunoprecipitation
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Alias: __
Gene Symbols: __
Isotype: IgG1
Purification Method: Protein A purified
Test Specificity: NB100-64825 reacts with human J chain as tested by ELISA using purified human Ig fragments as the solid phase target antigen. The antibody does not detect J chain in intact IgM in ELISA assays due to steric hindrance. In Western blotting techniques NB100-64825 detects J chain in IgM only in reducing conditions.
Clone: Mc19-9
Dilution: Western Blot 1:100-1:2000, ELISA 20 ug/ml, Immunohistochemistry 1:10-1:500, Immunoprecipitation 20 ug/ml, Immunohistochemistry-Frozen 1:200
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: Human J Chain
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Antigen: GFR alpha-4/GDNF R alpha-4/Persephin receptor
Concentration: LYOPH
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Alias: GDNF family receptor alpha 4, GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR receptor alpha 4, GFR-alpha-4, Persephin receptor
Gene Symbols: GFRA4
Isotype: IgG1
Purification Method: Protein G purified
Test Specificity: __
Clone: MM0311-3P34
Dilution: __
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Gene Accession No.: NP_071422
Gene ID (Entrez): 64096
Immunogen: __
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
