7214624
CD3 Mouse, anti-Human, R718, Clone: UCHT1, BD Horizon™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD3
Applications
Flow Cytometry
Conjugate
R718
Host Species
Mouse
Target Species
Human
Content And Storage
Refrigerate Upon Arrival
Clone
UCHT1
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Primary or Secondary
Primary
Description
- The UCHT1 monoclonal antibody specifically binds to the human CD3ε-chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex
- CD3ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes
- Studies from the HLDA Workshop show that this antibody is mitogenic for CD3ε-positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody
- CD3 plays a central role in signal transduction during antigen recognition
- The UCHT1 antibody stains both surface and intracellular CD3ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3ε.
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