7215077
Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9), APC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
Phospho-Chk1 (Ser345)
Applications
Flow Cytometry
Conjugate
APC
Host Species
Rabbit
Target Species
Human, Mouse, Rat
Gene Accession No.
O14757, O35280, Q91ZN7
Gene ID (Entrez)
1111, 12649, 140583
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Chek1
Clone
Chk1S345-R3F9
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols
Chek1
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Description
- CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
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Antigen: Phospho-Chk1 (Ser345)
Applications: Flow Cytometry
Conjugate: APC
Host Species: Rabbit
Target Species: Human, Mouse, Rat
Gene Accession No.: O14757, O35280, Q91ZN7
Gene ID (Entrez): 1111, 12649, 140583
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Chek1
Clone: Chk1S345-R3F9
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols: Chek1
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Chk1 (Ser345)
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Rabbit
Target Species:
Human, Mouse, Rat
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene ID (Entrez):
1111, 12649, 140583
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Chek1
Clone:
Chk1S345-R3F9
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols:
Chek1
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-HCLS1 (Tyr397)
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P14317, P49710
Gene ID (Entrez): 15163, 3059
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr397 of human phospho HS1.
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark
Gene: HCLS1
Clone: HS1Y397-F12
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: AW213261; CTTNL; HCLS1; hematopoietic cell specific Lyn substrate 1; hematopoietic cell-specific Lyn substrate 1; Hematopoietic lineage cell-specific protein; HS1; LckBP1; p75
Gene Symbols: HCLS1
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-HCLS1 (Tyr397)
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P14317, P49710
Gene ID (Entrez):
15163, 3059
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr397 of human phospho HS1.
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark
Gene:
HCLS1
Clone:
HS1Y397-F12
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
AW213261; CTTNL; HCLS1; hematopoietic cell specific Lyn substrate 1; hematopoietic cell-specific Lyn substrate 1; Hematopoietic lineage cell-specific protein; HS1; LckBP1; p75
Gene Symbols:
HCLS1
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-Chk1 (Ser317)
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: O14757, O35280
Gene ID (Entrez): 1111, 12649
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1.
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark
Gene: Chek1
Clone: chk1S317-F10
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols: Chek1
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Chk1 (Ser317)
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
O14757, O35280
Gene ID (Entrez):
1111, 12649
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1.
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark
Gene:
Chek1
Clone:
chk1S317-F10
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols:
Chek1
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-MAP2K4 (Ser257)
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rabbit
Target Species: Human, Mouse, Non-human Primate, Rat
Gene Accession No.: P45985, P47809
Gene ID (Entrez): 26398, 287398, 6416
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4.
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark
Gene: MAP2K4
Clone: SEK1MKK4S257-C5
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: C-JUN N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; JNKK1; MAP kinase activator 2; MAP kinase kinase 4; Map2k4; map2k4.L; map2k4a; map2k4-a; map2k4-b; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; mitogen activated protein kinase kinase 4; mitogen activated protein kinase kinase 4, variant 1; mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4 L homeolog; mitogen-activated protein kinase kinase 4a; MKK4; mkk4a; MKK4A-l; PRKMK4; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SAPKK1; SAPKK-1; Sek1; Serk1; Skk1; Stress-activated protein kinase kinase 1; XELAEV_18044157mg; XMEK2; zgc:136500; zMKK4 protein
Gene Symbols: MAP2K4
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-MAP2K4 (Ser257)
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rabbit
Target Species:
Human, Mouse, Non-human Primate, Rat
Gene Accession No.:
P45985, P47809
Gene ID (Entrez):
26398, 287398, 6416
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4.
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark
Gene:
MAP2K4
Clone:
SEK1MKK4S257-C5
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
C-JUN N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; JNKK1; MAP kinase activator 2; MAP kinase kinase 4; Map2k4; map2k4.L; map2k4a; map2k4-a; map2k4-b; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; mitogen activated protein kinase kinase 4; mitogen activated protein kinase kinase 4, variant 1; mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4 L homeolog; mitogen-activated protein kinase kinase 4a; MKK4; mkk4a; MKK4A-l; PRKMK4; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SAPKK1; SAPKK-1; Sek1; Serk1; Skk1; Stress-activated protein kinase kinase 1; XELAEV_18044157mg; XMEK2; zgc:136500; zMKK4 protein
Gene Symbols:
MAP2K4
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody