7215109
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), PE, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rabbit
Target Species
Human
Gene Accession No.
O14965, Q96GD4, Q9UQB9
Gene ID (Entrez)
6790, 6795, 9212
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Aurka
Clone
AuroraABC-CC12
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Gene Symbols
Aurka, Aurkb, AURKC
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Description
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis
- The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly
- Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis
- Required for central/midzone spindle assembly and cleavage furrow formation
- Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515)
- AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP
- Phosphorylation of INCENP leads to increased AURKB activity
- Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3
- A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres
- Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively)
- A positive feedback between GSG2 and AURKB contributes to CPC localization
- AURKB is also required for kinetochore localization of BUB1 and SGOL1
- Phosphorylation of p53/TP53 negatively regulates its transcriptional activity
- Key regulator of active promoters in resting B- and T-lymphocytes.
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Antigen: Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rabbit
Target Species: Human
Gene Accession No.: O14965, Q96GD4, Q9UQB9
Gene ID (Entrez): 6790, 6795, 9212
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Aurka
Clone: AuroraABC-CC12
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Gene Symbols: Aurka, Aurkb, AURKC
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
O14965, Q96GD4, Q9UQB9
Gene ID (Entrez):
6790, 6795, 9212
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Aurka
Clone:
AuroraABC-CC12
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Gene Symbols:
Aurka, Aurkb, AURKC
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-Btk (Tyr551)
Applications: Flow Cytometry
Conjugate: APC
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q06187
Gene ID (Entrez): 695
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: BTK
Clone: BtkY551-G12
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
Gene Symbols: BTK
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Btk (Tyr551)
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q06187
Gene ID (Entrez):
695
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
BTK
Clone:
BtkY551-G12
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
Gene Symbols:
BTK
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-Btk (Tyr551)
Applications: Flow Cytometry
Conjugate: APC
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q06187
Gene ID (Entrez): 695
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: BTK
Clone: BtkY551-G12
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
Gene Symbols: BTK
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Btk (Tyr551)
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q06187
Gene ID (Entrez):
695
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
BTK
Clone:
BtkY551-G12
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency
Gene Symbols:
BTK
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Applications: Flow Cytometry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: O14965, Q96GD4, Q9UQB9
Gene ID (Entrez): 6790, 6795, 9212
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Primary or Secondary: Primary
Content And Storage: -20°C
Gene: Aurka
Clone: AuroraABC-CC12
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Alias: Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Gene Symbols: Aurka, Aurkb, AURKC
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
O14965, Q96GD4, Q9UQB9
Gene ID (Entrez):
6790, 6795, 9212
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Primary or Secondary:
Primary
Content And Storage:
-20°C
Gene:
Aurka
Clone:
AuroraABC-CC12
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Alias:
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Gene Symbols:
Aurka, Aurkb, AURKC
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody