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7215208

Phospho-Histone H2A.X (Ser139) Recombinant Rabbit Monoclonal Antibody (HisH2AXS139-1B3), PE, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-Histone H2A.X (Ser139)

Applications

Flow Cytometry

Conjugate

PE

Host Species

Rabbit

Target Species

Human, Mouse

Gene Accession No.

P16104, P27661

Gene ID (Entrez)

15270, 3014

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.

Primary or Secondary

Primary

Content And Storage

4° C

Gene

H2AX

Clone

HisH2AXS139-1B3

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias

AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Gene Symbols

H2AX

Isotype

IgG κ

Purification Method

Protein A/G

Product Type

Antibody

Description

  • Description Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
  • In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
  • The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
  • The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
  • Structurally, H2A.x contains 143 amino acid residues
  • Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
  • There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
  • The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
  • Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
  • Histone H2A.x contributes to histone-formation and therefore the structure of DNA
  • Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.

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Fischer Scientific

7215208

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-Histone H2A.X (Ser139)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P16104, P27661
Gene ID (Entrez):
15270, 3014
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
H2AX
Clone:
HisH2AXS139-1B3
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Gene Symbols:
H2AX
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody

Img

Fischer Scientific

7215209

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-PTEN (Ser380)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
O08586, P60484
Gene ID (Entrez):
19211, 5728
Immunogen:
A synthetic phospho peptide corresponding to residues surrounding Ser380 of human phospho PTEN.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
PTEN
Clone:
PTENS380-NA9
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1
Gene Symbols:
PTEN
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody

Img

Fischer Scientific

7215209

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-PTEN (Ser380)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
O08586, P60484
Gene ID (Entrez):
19211, 5728
Immunogen:
A synthetic phospho peptide corresponding to residues surrounding Ser380 of human phospho PTEN.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
PTEN
Clone:
PTENS380-NA9
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1
Gene Symbols:
PTEN
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody

Img

Fischer Scientific

7215210

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-PLK1 (Thr210)
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P53350
Gene ID (Entrez):
5347
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1.
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark
Gene:
Plk1
Clone:
PLK1T210-C2
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg
Gene Symbols:
Plk1
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody