7215246

Phospho-Src (Tyr416) Recombinant Rabbit Monoclonal Antibody (SrcY416-C4), PE, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-Src (Tyr416)

Applications

Flow Cytometry

Conjugate

PE

Host Species

Rabbit

Target Species

Human, Mouse

Gene Accession No.

P05480, P12931

Gene ID (Entrez)

20779, 6714

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr416 of human phospho Src.

Primary or Secondary

Primary

Content And Storage

4° C

Gene

SRC

Clone

SrcY416-C4

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias

ASV; AW259666; csrc; c-SRC; c-src protein, C terminus; EC 2.7.10.2; fc54g04; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; ORF; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; protein-tyrosine kinase; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; sb:cb864; SDR; src; src downstream region; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; Unknown; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogen

Gene Symbols

SRC

Isotype

IgG κ

Purification Method

Protein A/G

Product Type

Antibody

Description

  • SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth
  • SRC is involved in the regulation of growth and differentiation of eukaryotic cells
  • SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis
  • In humans, the gene encoding SRC is present on chromosome 20
  • Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects
  • Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity
  • Mutations in the SRC gene could be involved in the malignant progression of colon cancer
  • Two transcript variants encoding the same SRC protein have been found thus far.

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Fischer Scientific

7215246

Rabbit Recombinant Monoclonal Antib...


Antigen:
Phospho-Src (Tyr416)

Applications:
Flow Cytometry

Conjugate:
PE

Host Species:
Rabbit

Target Species:
Human, Mouse

Gene Accession No.:
P05480, P12931

Gene ID (Entrez):
20779, 6714

Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr416 of human phospho Src.

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
SRC

Clone:
SrcY416-C4

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias:
ASV; AW259666; csrc; c-SRC; c-src protein, C terminus; EC 2.7.10.2; fc54g04; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; ORF; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; protein-tyrosine kinase; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; sb:cb864; SDR; src; src downstream region; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; Unknown; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogen

Gene Symbols:
SRC

Isotype:
IgG κ

Purification Method:
Protein A/G

Product Type:
Antibody

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Fischer Scientific

7215248

Rabbit Recombinant Monoclonal Antib...


Antigen:
Phospho-c-Cbl (Tyr700)

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Rabbit

Target Species:
Human, Mouse, Rat

Gene Accession No.:
P22681, P22682

Gene ID (Entrez):
12402, 500985, 867

Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr700 of human phospho c-Cbl.

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Cbl

Clone:
CblY700-E1

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias:
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL

Gene Symbols:
Cbl

Isotype:
IgG κ

Purification Method:
Protein A/G

Product Type:
Antibody

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7215249

Rabbit Recombinant Monoclonal Antib...


Antigen:
Phospho-PLK1 (Thr210)

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Rabbit

Target Species:
Human

Gene Accession No.:
P53350

Gene ID (Entrez):
5347

Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1.

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Plk1

Clone:
PLK1T210-C2

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias:
cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg

Gene Symbols:
Plk1

Isotype:
IgG κ

Purification Method:
Protein A/G

Product Type:
Antibody

Img

Fischer Scientific

7215249

Rabbit Recombinant Monoclonal Antib...


Antigen:
Phospho-PLK1 (Thr210)

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Rabbit

Target Species:
Human

Gene Accession No.:
P53350

Gene ID (Entrez):
5347

Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1.

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Plk1

Clone:
PLK1T210-C2

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias:
cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg

Gene Symbols:
Plk1

Isotype:
IgG κ

Purification Method:
Protein A/G

Product Type:
Antibody