7218700

CD8b Monoclonal Antibody (eBio341 (341)), Functional Grade, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

CD8b

Concentration

1 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with no preservative; pH 7.2

Gene ID (Entrez)

24931

Primary or Secondary

Primary

Content And Storage

4° C

Gene

Cd8b

Clone

eBio341 (341)

Applications

Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)

Conjugate

Functional Grade

Host Species

Mouse

Target Species

Rat

Gene Accession No.

P05541

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

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Description

  • The eBio341 MAb reacts with rat CD8beta
  • CD8beta is a member of the immunoglobulin superfamily which heterodimerizes with CD8alpha to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages
  • CD8beta expression is absent in athymic mice, which are populated by T-cells expressing CD8alpha homodimers
  • This has led to the idea that CD8beta expression is dependent on the development of T cells in the thymus
  • CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck
  • The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules
  • The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain
  • Both alpha and beta chains share significant homology to immunoglobulin variable light chains
  • This gene encodes the CD8 beta chain isoforms
  • Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described
  • A pseudogene, also located on chromosome 2, has been identified.

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Fischer Scientific

7218700

Mouse Monoclonal Antibody...


Antigen:
CD8b

Concentration:
1 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with no preservative; pH 7.2

Gene ID (Entrez):
24931

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Cd8b

Clone:
eBio341 (341)

Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)

Conjugate:
Functional Grade

Host Species:
Mouse

Target Species:
Rat

Gene Accession No.:
P05541

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Mouse Monoclonal Antibody...


Antigen:
CD24

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
100133941

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Cd24

Clone:
eBioSN3 (SN3 A5-2H10)

Applications:
Flow Cytometry

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
P25063

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Antigen:
CD289 (TLR9)

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
81897

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Tlr9

Clone:
M9.D6

Applications:
Flow Cytometry, Western Blot

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Mouse

Gene Accession No.:
Q9EQU3

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Antigen:
CD289 (TLR9)

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
81897

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Tlr9

Clone:
M9.D6

Applications:
Flow Cytometry, Western Blot

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Mouse

Gene Accession No.:
Q9EQU3

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody