7222845
CD45.2 Monoclonal Antibody (104), Brilliant Ultra Violet™ 805, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD45.2
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Gene Accession No.
P06800
Gene ID (Entrez)
19264
Isotype
IgG2a κ
Purification Method
Affinity chromatography
Gene
Ptprc
Clone
104
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 805
Host Species
Mouse
Target Species
Mouse
Gene Alias
B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
Gene Symbols
Ptprc
Primary or Secondary
Primary
Product Type
Antibody
Related Products
Description
- The 104 monoclonal antibody reacts with the mouse CD45 molecule, the leukocyte common antigen (LCA) in CD45.2-expressing mouse strains
- The strains that express CD45.2 include the most commonly used mouse strains C57BL/6, BALB/c, C58, DBA/1, DBA/2, C3H/He, CBA, 129, A and AKR
- CD45.2 is expressed by all leukocytes in these strains
- Applications Reported: This 104 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This 104 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This may be used at less than or equal to 1.0 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Brilliant Ultraviolet 805 is a tandem dye that emits at 797 nm and is intended for use on cytometers equipped with an ultraviolet (355 nm) laser
- CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes
- CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases
- CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains
- These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell
- Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis
- CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
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Antigen: CD45.2
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Gene Accession No.: P06800
Gene ID (Entrez): 19264
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Gene: Ptprc
Clone: 104
Applications: Flow Cytometry
Conjugate: Brilliant Ultraviolet 805
Host Species: Mouse
Target Species: Mouse
Gene Alias: B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
Gene Symbols: Ptprc
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
CD45.2
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Gene Accession No.:
P06800
Gene ID (Entrez):
19264
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Gene:
Ptprc
Clone:
104
Applications:
Flow Cytometry
Conjugate:
Brilliant Ultraviolet 805
Host Species:
Mouse
Target Species:
Mouse
Gene Alias:
B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
Gene Symbols:
Ptprc
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: CD45
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Gene Accession No.: P08575
Gene ID (Entrez): 5788
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Gene: PTPRC
Clone: HI30
Applications: Flow Cytometry
Conjugate: Brilliant Ultraviolet 805
Host Species: Mouse
Target Species: Human
Gene Alias: B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220
Gene Symbols: PTPRC
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
CD45
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Gene Accession No.:
P08575
Gene ID (Entrez):
5788
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Gene:
PTPRC
Clone:
HI30
Applications:
Flow Cytometry
Conjugate:
Brilliant Ultraviolet 805
Host Species:
Mouse
Target Species:
Human
Gene Alias:
B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220
Gene Symbols:
PTPRC
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: CD56 (NCAM)
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Gene Accession No.: P13591
Gene ID (Entrez): 4684, 693789
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Gene: Ncam1
Clone: TULY56
Applications: Flow Cytometry
Conjugate: Brilliant Ultraviolet 805
Host Species: Mouse
Target Species: Human, Non-human Primate, Rhesus Monkey
Gene Alias: adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Symbols: Ncam1
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
CD56 (NCAM)
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Gene Accession No.:
P13591
Gene ID (Entrez):
4684, 693789
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Gene:
Ncam1
Clone:
TULY56
Applications:
Flow Cytometry
Conjugate:
Brilliant Ultraviolet 805
Host Species:
Mouse
Target Species:
Human, Non-human Primate, Rhesus Monkey
Gene Alias:
adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Symbols:
Ncam1
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: CD62L (L-Selectin)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Gene Accession No.: P18337
Gene ID (Entrez): 20343
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Gene: SELL
Clone: MEL-14
Applications: Flow Cytometry
Conjugate: Brilliant Ultraviolet 805
Host Species: Rat
Target Species: Mouse
Gene Alias: A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1
Gene Symbols: SELL
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
CD62L (L-Selectin)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Gene Accession No.:
P18337
Gene ID (Entrez):
20343
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Gene:
SELL
Clone:
MEL-14
Applications:
Flow Cytometry
Conjugate:
Brilliant Ultraviolet 805
Host Species:
Rat
Target Species:
Mouse
Gene Alias:
A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1
Gene Symbols:
SELL
Primary or Secondary:
Primary
Product Type:
Antibody