BD Horizon™ CD54 (ICAM-1) Mouse, anti-Human, RY586, Clone: HA58, BD Horizon™

Description

• The HA58 monoclonal antibody specifically binds to CD54 which is also known as ICAM-1 (intracellular adhesion molecule-1).  CD54 is an 85-110 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin supergene family
• A soluble form of CD54 can also be found in biological fluids
• CD54 is expressed on endothelial cells and both resting (weak) and activated (moderate) lymphocytes and monocytes
• CD54 is a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)
• The CD54 adhesion molecule plays roles in inflammatory and immune responses and neoplasia
• This antibody (NA/LE format) blocks the mixed-lymphocyte reaction (MLR) and the purified format is suitable for staining acetone-fixed, frozen tissue sections.