7245057
IL-22 Polyclonal Antibody, PeproTech®, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
IL-22
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q9GZX6
Gene ID (Entrez)
50616
Immunogen
E.coli-derived Recombinant Human IL-22
Purification Method
Antigen affinity chromatography
Gene
IL22
Concentration
0.1-1.0 mg/mL
Classification
Polyclonal
Form
Lyophilized
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
Gene Symbols
IL22
Primary or Secondary
Primary
Content And Storage
-20°C
Related Products
Description
- AA Sequence of recombinant protein: MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
- Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-22
- Anti-Human IL-22-specific antibody was purified by affinity chromatography employing an immobilized Human IL-22 matrix
- Sandwich ELISA: To detect Human IL-22 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required
- This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human IL-22 (500-P211Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human IL-22
- Western Blot: To detect Human IL-22 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
- Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human IL-22 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
- IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons
- IL-22 is produced mainly by activated T cells and NK cells
- In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10
- IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2
- IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29
- Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway
- In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling
- IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes
- IL-22 has been described as an effector cytokine of the Th17 lineage
- Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin
- IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated
- The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes
- IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors
- IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses
- IL-22 is upregulated in activated T cells
- IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.
Compare Similar Items
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Antigen: IL-22
Applications: ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q9GZX6
Gene ID (Entrez): 50616
Immunogen: E.coli-derived Recombinant Human IL-22
Purification Method: Antigen affinity chromatography
Gene: IL22
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
Gene Symbols: IL22
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
IL-22
Applications:
ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q9GZX6
Gene ID (Entrez):
50616
Immunogen:
E.coli-derived Recombinant Human IL-22
Purification Method:
Antigen affinity chromatography
Gene:
IL22
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
Gene Symbols:
IL22
Primary or Secondary:
Primary
Content And Storage:
-20°C
Antigen: CTGF
Applications: ELISA, Western Blot
Conjugate: Biotin
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P29279
Gene ID (Entrez): 1490
Immunogen: E.coli-derived Recombinant Human CTGF
Purification Method: Antigen affinity chromatography
Gene: CCN2
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: 2-Nov; betaIG-M2; CCN family member 2; Ccn2; Cellular communication network factor 2; connective tissue growth factor; connective tissue growth factor precursor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); connective tissue growth-related protein; CTGF; CTGF protein; CTGRP; fibroblast inducible secreated protein; fibroblast inducible secreted protein; Fisp12; fisp-12; Hcs24; H-CTGF; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839; NOV2; Protein FISP-12; similar to connective tissue growth factor precursor
Gene Symbols: CCN2
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
CTGF
Applications:
ELISA, Western Blot
Conjugate:
Biotin
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P29279
Gene ID (Entrez):
1490
Immunogen:
E.coli-derived Recombinant Human CTGF
Purification Method:
Antigen affinity chromatography
Gene:
CCN2
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
2-Nov; betaIG-M2; CCN family member 2; Ccn2; Cellular communication network factor 2; connective tissue growth factor; connective tissue growth factor precursor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); connective tissue growth-related protein; CTGF; CTGF protein; CTGRP; fibroblast inducible secreated protein; fibroblast inducible secreted protein; Fisp12; fisp-12; Hcs24; H-CTGF; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839; NOV2; Protein FISP-12; similar to connective tissue growth factor precursor
Gene Symbols:
CCN2
Primary or Secondary:
Primary
Content And Storage:
-20°C
Antigen: PlGF-1
Applications: ELISA, Western Blot
Conjugate: Biotin
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P49763
Gene ID (Entrez): 5228
Immunogen: E.coli-derived, 29.7 kDa Recombinant Human PlGF-1
Purification Method: Antigen affinity chromatography
Gene: PGF
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: __
Gene Symbols: PGF
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
PlGF-1
Applications:
ELISA, Western Blot
Conjugate:
Biotin
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P49763
Gene ID (Entrez):
5228
Immunogen:
E.coli-derived, 29.7 kDa Recombinant Human PlGF-1
Purification Method:
Antigen affinity chromatography
Gene:
PGF
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
__
Gene Symbols:
PGF
Primary or Secondary:
Primary
Content And Storage:
-20°C
Antigen: CD267 (TACI)
Applications: ELISA, Western Blot
Conjugate: Biotin
Host Species: Goat
Target Species: Human
Gene Accession No.: O14836
Gene ID (Entrez): 23495
Immunogen: E.coli-derived, 17.8 kDa Recombinant Human TACI
Purification Method: Antigen affinity chromatography
Gene: TNFRSF13B
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: 1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
Gene Symbols: TNFRSF13B
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
CD267 (TACI)
Applications:
ELISA, Western Blot
Conjugate:
Biotin
Host Species:
Goat
Target Species:
Human
Gene Accession No.:
O14836
Gene ID (Entrez):
23495
Immunogen:
E.coli-derived, 17.8 kDa Recombinant Human TACI
Purification Method:
Antigen affinity chromatography
Gene:
TNFRSF13B
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
Gene Symbols:
TNFRSF13B
Primary or Secondary:
Primary
Content And Storage:
-20°C