7245244
IL-21 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
IL-21
Applications
ELISA, Western Blot
Conjugate
Biotin
Host Species
Rabbit
Target Species
Mouse
Gene Accession No.
Q9ES17
Gene ID (Entrez)
60505
Immunogen
E.coli-derived Recombinant Murine IL-21
Purification Method
Antigen affinity chromatography
Gene
IL21
Concentration
0.1-1.0 mg/mL
Classification
Polyclonal
Form
Lyophilized
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Gene Symbols
IL21
Primary or Secondary
Primary
Content And Storage
-20°C
Related Products
Description
- AA Sequence of recombinant protein: MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS
- Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-21
- Anti-Murine IL-21-specific antibody was purified by affinity chromatography and then biotinylated
- Sandwich ELISA: To detect mIL-21 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required
- This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Murine IL-21 (500-P278) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant mIL-21
- Western Blot: To detect mIL-21 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
- Used in conjunction with compatible secondary reagents the detection limit for Recombinant mIL-21 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
- 500-P278BT-1MG will be provided as 2 x 500 μg IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells
- In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6
- As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function
- IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells
- In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23
- While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3
- IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules
- In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
Compare Similar Items
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Antigen: IL-21
Applications: ELISA, Western Blot
Conjugate: Biotin
Host Species: Rabbit
Target Species: Mouse
Gene Accession No.: Q9ES17
Gene ID (Entrez): 60505
Immunogen: E.coli-derived Recombinant Murine IL-21
Purification Method: Antigen affinity chromatography
Gene: IL21
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Gene Symbols: IL21
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
IL-21
Applications:
ELISA, Western Blot
Conjugate:
Biotin
Host Species:
Rabbit
Target Species:
Mouse
Gene Accession No.:
Q9ES17
Gene ID (Entrez):
60505
Immunogen:
E.coli-derived Recombinant Murine IL-21
Purification Method:
Antigen affinity chromatography
Gene:
IL21
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Gene Symbols:
IL21
Primary or Secondary:
Primary
Content And Storage:
-20°C
Antigen: CXCL16
Applications: ELISA, Western Blot
Conjugate: Biotin
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q9H2A7
Gene ID (Entrez): 58191
Immunogen: E.coli-derived Recombinant Human CXCL16
Purification Method: Antigen affinity chromatography
Gene: Cxcl16
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: 0910001K24Rik; AV290116; b2b498Clo; BB024863; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 16; CXC; Cxc chemokine ligand 16; CXC motif chemokine; C-X-C motif chemokine 16; C-X-C motif chemokine ligand 16; CXCL; Cxcl16; CXCL16v1; CXCL16v2; CXCLG16; Mutant line 498; scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SCYB16; Small-inducible cytokine B16; Srpsox; SR-PSOX; SR-PSOX/CXCL16; Transmembrane chemokine CXCL16; UNQ2759/PRO6714; zinc finger, MYND-type containing 15; Zmynd15
Gene Symbols: Cxcl16
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
CXCL16
Applications:
ELISA, Western Blot
Conjugate:
Biotin
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q9H2A7
Gene ID (Entrez):
58191
Immunogen:
E.coli-derived Recombinant Human CXCL16
Purification Method:
Antigen affinity chromatography
Gene:
Cxcl16
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
0910001K24Rik; AV290116; b2b498Clo; BB024863; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 16; CXC; Cxc chemokine ligand 16; CXC motif chemokine; C-X-C motif chemokine 16; C-X-C motif chemokine ligand 16; CXCL; Cxcl16; CXCL16v1; CXCL16v2; CXCLG16; Mutant line 498; scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SCYB16; Small-inducible cytokine B16; Srpsox; SR-PSOX; SR-PSOX/CXCL16; Transmembrane chemokine CXCL16; UNQ2759/PRO6714; zinc finger, MYND-type containing 15; Zmynd15
Gene Symbols:
Cxcl16
Primary or Secondary:
Primary
Content And Storage:
-20°C
Antigen: Rheumatoid Factor
Applications: ELISA
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: Purified proteins from patients with IgM cryoglobulins.
Purification Method: Protein G
Gene: __
Concentration: 1.76 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.4
Gene Alias: RF
Gene Symbols: __
Primary or Secondary: Primary
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Antigen:
Rheumatoid Factor
Applications:
ELISA
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
Purified proteins from patients with IgM cryoglobulins.
Purification Method:
Protein G
Gene:
__
Concentration:
1.76 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.4
Gene Alias:
RF
Gene Symbols:
__
Primary or Secondary:
Primary
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Antigen: TGF beta-3
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P10600
Gene ID (Entrez): 7043
Immunogen: E.coli-derived Recombinant Human TGF-beta3
Purification Method: Antigen affinity chromatography
Gene: TGFB3
Concentration: 0.1-1.0 mg/mL
Classification: Polyclonal
Form: Lyophilized
Regulatory Status: RUO
Formulation: PBS with no preservative
Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Gene Symbols: TGFB3
Primary or Secondary: Primary
Content And Storage: -20°C
Antigen:
TGF beta-3
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P10600
Gene ID (Entrez):
7043
Immunogen:
E.coli-derived Recombinant Human TGF-beta3
Purification Method:
Antigen affinity chromatography
Gene:
TGFB3
Concentration:
0.1-1.0 mg/mL
Classification:
Polyclonal
Form:
Lyophilized
Regulatory Status:
RUO
Formulation:
PBS with no preservative
Gene Alias:
ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Gene Symbols:
TGFB3
Primary or Secondary:
Primary
Content And Storage:
-20°C