89-018-075
CHK2 checkpoint homolog (S. pombe), Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-018-075-Each-of-1 | In Stock | ₹ 47,742.48 |
89-018-075 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,742.48
GST (18%): ₹ 8,593.646
Total Price: ₹ 56,336.126
Antigen
CHK2 checkpoint homolog (S. pombe)
Classification
Polyclonal
Description
Rabbit polyclonal antibody raised against a full-length human CHEK2 protein.
Gene
CHEK2
Gene Alias
CDS1/CHK2/HuCds1/LFS2/PP1425/RAD53
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Applications
Western Blot
Conjugate
Unconjugated
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
NM_007194.3
Gene Symbols
CHEK2
Immunogen
CHEK2 (NP_009125.1, 1 a.a. ∼ 543 a.a) full-length human protein.
Quantity
100 μg
Research Discipline
Cell Cycle
Gene ID (Entrez)
11200
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype
IgG
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Description
- In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators
- The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor
- It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage
- When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1
- In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage
- Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53
- Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors
- This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases
- Three transcript variants encoding different isoforms have been found for this gene
- [provided by RefSeq Sequence: MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
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Antigen: CHK2 checkpoint homolog (S. pombe)
Classification: Polyclonal
Description: Rabbit polyclonal antibody raised against a full-length human CHEK2 protein.
Gene: CHEK2
Gene Alias: CDS1/CHK2/HuCds1/LFS2/PP1425/RAD53
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Applications: Western Blot
Conjugate: Unconjugated
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: NM_007194.3
Gene Symbols: CHEK2
Immunogen: CHEK2 (NP_009125.1, 1 a.a. ∼ 543 a.a) full-length human protein.
Quantity: 100 μg
Research Discipline: Cell Cycle
Gene ID (Entrez): 11200
Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype: IgG
Antigen:
CHK2 checkpoint homolog (S. pombe)
Classification:
Polyclonal
Description:
Rabbit polyclonal antibody raised against a full-length human CHEK2 protein.
Gene:
CHEK2
Gene Alias:
CDS1/CHK2/HuCds1/LFS2/PP1425/RAD53
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
NM_007194.3
Gene Symbols:
CHEK2
Immunogen:
CHEK2 (NP_009125.1, 1 a.a. ∼ 543 a.a) full-length human protein.
Quantity:
100 μg
Research Discipline:
Cell Cycle
Gene ID (Entrez):
11200
Content And Storage:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG
Antigen: interleukin-1 receptor-associated kinase 3
Classification: Polyclonal
Description: Rabbit polyclonal antibody raised against a full-length human IRAK3 protein.
Gene: IRAK3
Gene Alias: ASRT5/FLJ13601/IRAK-M/IRAKM
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Applications: Western Blot
Conjugate: Unconjugated
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: NM_007199.1
Gene Symbols: IRAK3
Immunogen: IRAK3 (NP_009130.1, 1 a.a. ∼ 596 a.a) full-length human protein.
Quantity: 100 μg
Research Discipline: Kinases
Gene ID (Entrez): 11213
Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype: IgG
Antigen:
interleukin-1 receptor-associated kinase 3
Classification:
Polyclonal
Description:
Rabbit polyclonal antibody raised against a full-length human IRAK3 protein.
Gene:
IRAK3
Gene Alias:
ASRT5/FLJ13601/IRAK-M/IRAKM
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
NM_007199.1
Gene Symbols:
IRAK3
Immunogen:
IRAK3 (NP_009130.1, 1 a.a. ∼ 596 a.a) full-length human protein.
Quantity:
100 μg
Research Discipline:
Kinases
Gene ID (Entrez):
11213
Content And Storage:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG
Antigen: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Classification: Polyclonal
Description: Rabbit polyclonal antibody raised against a full-length human RASSF8 protein.
Gene: RASSF8
Gene Alias: C12orf2/HoJ-1
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Applications: Western Blot
Conjugate: Unconjugated
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: NM_007211.2
Gene Symbols: RASSF8
Immunogen: RASSF8 (NP_009142.2, 1 a.a. ∼ 392 a.a) full-length human protein.
Quantity: 100 μg
Research Discipline: Signal Transduction
Gene ID (Entrez): 11228
Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype: IgG
Antigen:
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Classification:
Polyclonal
Description:
Rabbit polyclonal antibody raised against a full-length human RASSF8 protein.
Gene:
RASSF8
Gene Alias:
C12orf2/HoJ-1
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
NM_007211.2
Gene Symbols:
RASSF8
Immunogen:
RASSF8 (NP_009142.2, 1 a.a. ∼ 392 a.a) full-length human protein.
Quantity:
100 μg
Research Discipline:
Signal Transduction
Gene ID (Entrez):
11228
Content And Storage:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG
Antigen: three prime repair exonuclease 1
Classification: Polyclonal
Description: Rabbit polyclonal antibody raised against a full-length human TREX1 protein.
Gene: TREX1
Gene Alias: AGS1/AGS5/CRV/DKFZp434J0310/DRN3/HERNS
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Applications: Western Blot
Conjugate: Unconjugated
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: NM_016381
Gene Symbols: TREX1
Immunogen: TREX1 (NP_057465.1, 1 a.a. ∼ 369 a.a) full-length human protein.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): 11277
Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype: IgG
Antigen:
three prime repair exonuclease 1
Classification:
Polyclonal
Description:
Rabbit polyclonal antibody raised against a full-length human TREX1 protein.
Gene:
TREX1
Gene Alias:
AGS1/AGS5/CRV/DKFZp434J0310/DRN3/HERNS
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
NM_016381
Gene Symbols:
TREX1
Immunogen:
TREX1 (NP_057465.1, 1 a.a. ∼ 369 a.a) full-length human protein.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
11277
Content And Storage:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG