F13A1, Mouse, Clone: AC-1A1, Abnova™

Description

• This gene encodes the coagulation factor XIII A subunit
• Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade
• Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits
• The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules
• Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin
• Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII
• This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
• It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin
• Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone
• These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion
• [provided by RefSeq