TP53, Mouse, Clone: SPM589, Abnova™

Description

• This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism
• p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy
• p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains
• It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor
• Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity
• Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
• Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found
• These variants encode distinct isoforms, which can regulate p53 transcriptional activity
• [provided by RefSeq]