89-131-799

CHEK2 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Manufacturer: Abnova Corporation

Select a Size

Pack Size SKU Availability Price
Each of 1 89-131-799-Each-of-1 In Stock ₹ 51,079.32

89-131-799 - Each of 1

₹ 51,079.32

In Stock

Quantity

1

Base Price: ₹ 51,079.32

GST (18%): ₹ 9,194.278

Total Price: ₹ 60,273.598

Antigen

CHEK2

Classification

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic peptide of CHEK2.

Formulation

In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

Gene Alias

CDS1/CHK2/HuCds1/LFS2/PP1425/RAD53

Host Species

Rabbit

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Form

Liquid

Applications

Immunohistochemistry (PFA fixed), Western Blot

Conjugate

Unconjugated

Dilution

Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.

Gene

CHEK2

Gene Symbols

CHEK2

Immunogen

A synthetic peptide corresponding to residues surrounding T68 of human CHEK2.

Regulatory Status

RUO

Gene ID (Entrez)

11200

Content And Storage

Store at -20°C.Aliquot to avoid repeated freezing and thawing.

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Description

  • In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators
  • The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor
  • It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage
  • When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1
  • In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage
  • Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53
  • Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors
  • This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases
  • Three transcript variants encoding different isoforms have been found for this gene
  • [provided by RefSeq

Compare Similar Items

Show Difference

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Abnova Corporation

89-131-799

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Antigen:
CHEK2

Classification:
Polyclonal

Description:
Rabbit polyclonal antibody raised against synthetic peptide of CHEK2.

Formulation:
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

Gene Alias:
CDS1/CHK2/HuCds1/LFS2/PP1425/RAD53

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Form:
Liquid

Applications:
Immunohistochemistry (PFA fixed), Western Blot

Conjugate:
Unconjugated

Dilution:
Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.

Gene:
CHEK2

Gene Symbols:
CHEK2

Immunogen:
A synthetic peptide corresponding to residues surrounding T68 of human CHEK2.

Regulatory Status:
RUO

Gene ID (Entrez):
11200

Content And Storage:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.

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89-131-800

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Antigen:
SLC5A7

Classification:
Polyclonal

Description:
Rabbit polyclonal antibody raised against synthetic peptide of SLC5A7.

Formulation:
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)

Gene Alias:
CHT/CHT1/MGC126299/MGC126300/hCHT

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Form:
Liquid

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Dilution:
The optimal working dilution should be determined by the end user.

Gene:
SLC5A7

Gene Symbols:
SLC5A7

Immunogen:
A synthetic peptide corresponding to C-terminus of human SLC5A7.

Regulatory Status:
RUO

Gene ID (Entrez):
60482

Content And Storage:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.

Img

Abnova Corporation

89-131-801

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Antigen:
CFL1

Classification:
Polyclonal

Description:
Rabbit polyclonal antibody raised against synthetic peptide of CFL1.

Formulation:
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

Gene Alias:
CFL

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Form:
Liquid

Applications:
Immunohistochemistry (PFA fixed), Western Blot

Conjugate:
Unconjugated

Dilution:
Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.

Gene:
CFL1

Gene Symbols:
CFL1

Immunogen:
A synthetic peptide corresponding to residues surrounding S3 of human CFL1.

Regulatory Status:
RUO

Gene ID (Entrez):
1072

Content And Storage:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.

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Antigen:
COL15A1

Classification:
Polyclonal

Description:
Rabbit polyclonal antibody raised against synthetic peptide of COL15A1.

Formulation:
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)

Gene Alias:
FLJ38566

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Form:
Liquid

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Dilution:
The optimal working dilution should be determined by the end user.

Gene:
COL15A1

Gene Symbols:
COL15A1

Immunogen:
A synthetic peptide corresponding to C-terminus of human COL15A1.

Regulatory Status:
RUO

Gene ID (Entrez):
1306

Content And Storage:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.