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89-934-279

HLA-DRB1 Mouse anti-Human, Clone: SPM423, Abnova™

Manufacturer: Abnova Corporation

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Each of 1 89-934-279-Each-of-1 In Stock ₹ 64,426.68

89-934-279 - Each of 1

₹ 64,426.68

In Stock

Quantity

1

Base Price: ₹ 64,426.68

GST (18%): ₹ 11,596.802

Total Price: ₹ 76,023.482

Antigen

HLA-DRB1

Classification

Monoclonal

Conjugate

Unconjugated

Dilution

Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d

Gene Alias

DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1

Host Species

Mouse

Purification Method

Protein A/G purification

Regulatory Status

RUO

Gene ID (Entrez)

3123

Target Species

Human

Form

Liquid

Applications

Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot

Clone

SPM423

Description

Mouse monoclonal antibody raised against native human HLA-DRB1.

Formulation

In 10mM PBS.

Gene Symbols

HLA-DRB1

Immunogen

Activated human peripheral blood mononuclear cells.

Quantity

100 μg

Primary or Secondary

Primary

Test Specificity

This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.

Content And Storage

Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.

Isotype

IgG2b κ

Description

  • HLA-DRB1 belongs to the HLA class II beta chain paralogs
  • The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane
  • It plays a central role in the immune system by presenting peptides derived from extracellular proteins
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
  • The beta chain is approximately 26-28 kDa
  • It is encoded by 6 exons
  • Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail
  • Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities
  • Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
  • DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5
  • DRB1 is present in all individuals
  • Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5
  • There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9
  • [provided by RefSeq]

Compare Similar Items

Show Difference

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Abnova Corporation

89-934-279

--

Antigen:
HLA-DRB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
SPM423
Description:
Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation:
In 10mM PBS.
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage:
Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG2b κ

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Abnova Corporation

89-934-280

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Antigen:
HMGB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Immunohistochemistry (1:10-1:50) Western Blot (1:500-1:1600) The optimal working dilution should be determined by the end user.
Gene Alias:
DKFZp686A04236/HMG1/HMG3/SBP-1
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Gene ID (Entrez):
3146
Target Species:
Human, Mouse
Form:
Liquid
Applications:
Immunohistochemistry (PFA fixed), Western Blot
Clone:
393CT23.1.4
Description:
Mouse monoclonal antibody raised against synthetic peptide of human HMGB1.
Formulation:
In ascites (0.09% sodium azide)
Gene Symbols:
HMGB1
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to amino acids 152-180 at C-terminus region of human HMGB1.
Quantity:
100 μL
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgM

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Abnova Corporation

89-934-285

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Antigen:
HNRNPA1
Classification:
Polyclonal
Conjugate:
Unconjugated
Dilution:
Immunohistochemistry (1:200-1:500) Immunofluorescence (1-4 ug/mL) Western Blot (1:100-1:250) The optimal working dilution should be determined by the end user.
Gene Alias:
HNRPA1/MGC102835
Host Species:
Rabbit
Purification Method:
Antigen affinity purification
Regulatory Status:
RUO
Gene ID (Entrez):
3178
Target Species:
Human
Form:
Liquid
Applications:
Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
__
Description:
Rabbit polyclonal antibody raised against recombinant human HNRNPA1.
Formulation:
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Gene Symbols:
HNRNPA1
Immunogen:
Recombinant protein corresponding to human HNRNPA1.
Quantity:
100 μL
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG

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89-934-286

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Antigen:
HNRNPA2B1
Classification:
Polyclonal
Conjugate:
Unconjugated
Dilution:
Immunohistochemistry (1:50-1:200) Western Blot (1:100-1:250) The optimal working dilution should be determined by the end user.
Gene Alias:
DKFZp779B0244/FLJ22720/HNRNPA2/HNRNPB1/HNRPA2/HNRPA2B1/HNRPB1/RNPA2/SNRPB1
Host Species:
Rabbit
Purification Method:
Antigen affinity purification
Regulatory Status:
RUO
Gene ID (Entrez):
3181
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunohistochemistry (PFA fixed), Western Blot
Clone:
__
Description:
Rabbit polyclonal antibody raised against recombinant human HNRNPA2B1.
Formulation:
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Gene Symbols:
HNRNPA2B1
Immunogen:
Recombinant protein corresponding to human HNRNPA2B1.
Quantity:
100 μL
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG