NMDAR2B Polyclonal Antibody, Invitrogen™

Description

• This antibody is specific for the ∽180 kDa 2B subunit from rat, mouse and human
• Storage and reconstitution: when stored at -20oC or below, the lyophilized antibody should retain full activity for over one year
• Reconstitute using 50 μL PBS, pH 7.4, to yield a 0.2 mg/mL solution
• If storing at 0-4oC, add sodium azide to a final concentration of 2mM
• For longer storage, divide the solution into aliquots and freeze at -20oC, avoiding freeze/thaw cycles
• NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors
• NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning
• NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death
• Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression
• Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity
• NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3
• Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.