ABN90325UG
Huntingtin, Rabbit anti-Mouse, Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN90325UG-Each-of-1 | In Stock | ₹ 16,456.61 |
ABN90325UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Huntingtin
Classification
Polyclonal
Dilution
Western Blotting Analysis: 2 μg/mL from a representative lot detected Huntingtin in mouse brain tissue lysate.
Gene Alias
Huntington disease protein;HD protein
Host Species
Rabbit
Molecular Weight of Antigen
347.60 kDa calculated.
Quantity
25 μg
Research Discipline
Neuroscience
Test Specificity
This rabbit polyclonal antibody detects Huntington disease protein in human and mouse brain. It targets an epitope within 180 amino acids from the N-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
HTT;HD;IT15
Immunogen
GST/His-tagged recombinant fragment corresponding to 180 amino acids from the N-terminal region of human Huntington disease protein .
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse, Human
Description
- Anti-Huntingtin, Cat
- No
- ABN903, is a highly specific rabbit polyclonal antibody that targets Huntington Disease Protein and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Huntingtin (UniProt: P42858; also known as Huntington disease protein, HD protein) is encoded by the HTT (also known as HD, IT15) gene (Gene ID: 3064) in human
- The protein is found in the perinuclear region along with microtubules, and in the centrosomal region along with gamma-tubulin
- It is expressed in the brain and is mainly found in the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation
- Huntingtin is necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis
- It plays a role in microtubule-mediated transport and vesicle function
- Huntingtin protein contains a nuclear export signal (aa 2395-2404) and 5 HEAT (Huntington, Elongation Factor 3, PR65/A, TOR) domains
- Huntingtin protein is cleaved by apopain downstream of the polyglutamine stretch and the resulting N-terminal fragment is cytotoxic and provokes apoptosis
- Phosphorylation at Serine 1179 and 1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity
- Mutations in HTT gene cause Huntington disease that is characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia
- Wild-type huntingtin and anti-huntingtin antibody reduces aggregation and cellular toxicity of the mutant huntingtin form in mammalian cell models of Huntington disease.
Compare Similar Items
Show Difference
Antigen: Huntingtin
Classification: Polyclonal
Dilution: Western Blotting Analysis: 2 μg/mL from a representative lot detected Huntingtin in mouse brain tissue lysate.
Gene Alias: Huntington disease protein;HD protein
Host Species: Rabbit
Molecular Weight of Antigen: 347.60 kDa calculated.
Quantity: 25 μg
Research Discipline: Neuroscience
Test Specificity: This rabbit polyclonal antibody detects Huntington disease protein in human and mouse brain. It targets an epitope within 180 amino acids from the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: HTT;HD;IT15
Immunogen: GST/His-tagged recombinant fragment corresponding to 180 amino acids from the N-terminal region of human Huntington disease protein .
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse, Human
Antigen:
Huntingtin
Classification:
Polyclonal
Dilution:
Western Blotting Analysis: 2 μg/mL from a representative lot detected Huntingtin in mouse brain tissue lysate.
Gene Alias:
Huntington disease protein;HD protein
Host Species:
Rabbit
Molecular Weight of Antigen:
347.60 kDa calculated.
Quantity:
25 μg
Research Discipline:
Neuroscience
Test Specificity:
This rabbit polyclonal antibody detects Huntington disease protein in human and mouse brain. It targets an epitope within 180 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
HTT;HD;IT15
Immunogen:
GST/His-tagged recombinant fragment corresponding to 180 amino acids from the N-terminal region of human Huntington disease protein .
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse, Human
Antigen: alpha-Synuclein
Classification: Polyclonal
Dilution: __
Gene Alias: Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Host Species: Rabbit
Molecular Weight of Antigen: ∽17 kDa observed; 14.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: This rabbit polyclonal antibody detects alpha synuclein in human, mouse, and rat. It targets an epitope with in 21 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Western Blot, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SNCA;NACP;PARK1
Immunogen: KLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminal region of human Alpha-Synuclein.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat, Human, Mouse
Antigen:
alpha-Synuclein
Classification:
Polyclonal
Dilution:
__
Gene Alias:
Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Host Species:
Rabbit
Molecular Weight of Antigen:
∽17 kDa observed; 14.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
This rabbit polyclonal antibody detects alpha synuclein in human, mouse, and rat. It targets an epitope with in 21 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SNCA;NACP;PARK1
Immunogen:
KLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminal region of human Alpha-Synuclein.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat, Human, Mouse
Antigen: alpha-Synuclein
Classification: Polyclonal
Dilution: __
Gene Alias: Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Host Species: Rabbit
Molecular Weight of Antigen: ∽17 kDa observed; 14.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μg
Research Discipline: Neuroscience
Test Specificity: This rabbit polyclonal antibody detects alpha synuclein in human, mouse, and rat. It targets an epitope with in 21 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Western Blot, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SNCA;NACP;PARK1
Immunogen: KLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminal region of human Alpha-Synuclein.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat, Human, Mouse
Antigen:
alpha-Synuclein
Classification:
Polyclonal
Dilution:
__
Gene Alias:
Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Host Species:
Rabbit
Molecular Weight of Antigen:
∽17 kDa observed; 14.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μg
Research Discipline:
Neuroscience
Test Specificity:
This rabbit polyclonal antibody detects alpha synuclein in human, mouse, and rat. It targets an epitope with in 21 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SNCA;NACP;PARK1
Immunogen:
KLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminal region of human Alpha-Synuclein.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat, Human, Mouse
Antigen: NeuN
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Guinea Pig
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: __
Test Specificity: __
Content And Storage: −20°C in undiluted aliquots for 12 months. Avoid repeated freeze/thaw cycles.
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Formulation: Guinea pig polyclonal serum containing 0.05% sodium azide.
Gene Symbols: __
Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of mouse NeuN.
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Mouse, Rat
Antigen:
NeuN
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Guinea Pig
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
__
Test Specificity:
__
Content And Storage:
−20°C in undiluted aliquots for 12 months. Avoid repeated freeze/thaw cycles.
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Formulation:
Guinea pig polyclonal serum containing 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminus of mouse NeuN.
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Mouse, Rat