AHO0152
p53 Monoclonal Antibody (DO-1), Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AHO0152-Each-of-1 | In Stock | ₹ 38,502.00 |
AHO0152 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,502.00
GST (18%): ₹ 6,930.36
Total Price: ₹ 45,432.36
Antigen
p53
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
P04637, P56424
Gene Symbols
Tp53
Immunogen
Recombinant human wild type p53 protein expressed in E. coli.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Rhesus Monkey
Product Type
Antibody
Isotype
IgG2a
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
DO-1
Conjugate
Unconjugated
Gene
Tp53
Gene Alias
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
7157, 716170
Content And Storage
-20°C
Form
Liquid
Description
- This antibody reacts with mutant and wild form p53
- It reacts with an epitope at aa 20-25
- Staining of formalin-fixed paraffin-embedded tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 20 min followed by cooling at room temperature for 20 min
- Recommended positive controls include SK-BR-3 cells, MDA-231 cells, and colon carcinoma
- The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress
- p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides
- p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest
- The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain
- There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization
- p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent
- Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors
- In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory
- p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy
- Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity
- Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
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Antigen: p53
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.: P04637, P56424
Gene Symbols: Tp53
Immunogen: Recombinant human wild type p53 protein expressed in E. coli.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human, Rhesus Monkey
Product Type: Antibody
Isotype: IgG2a
Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: DO-1
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 7157, 716170
Content And Storage: -20°C
Form: Liquid
Antigen:
p53
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.:
P04637, P56424
Gene Symbols:
Tp53
Immunogen:
Recombinant human wild type p53 protein expressed in E. coli.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG2a
Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
DO-1
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7157, 716170
Content And Storage:
-20°C
Form:
Liquid
Antigen: FAK
Classification: Polyclonal
Concentration: 1 mg/mL
Formulation: PBS with 0.2% BSA and 0.1% sodium azide; pH 7.3
Gene Accession No.: O35346, P34152, Q05397
Gene Symbols: PTK2
Immunogen: Recombinant protein corresponding to amino acid residues 853-1052 from theC-terminal region of human FAK.
Quantity: 500 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Clone: __
Conjugate: Unconjugated
Gene: PTK2
Gene Alias: CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel\CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 14083, 25614, 5747
Content And Storage: -20°C
Form: Liquid
Antigen:
FAK
Classification:
Polyclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.2% BSA and 0.1% sodium azide; pH 7.3
Gene Accession No.:
O35346, P34152, Q05397
Gene Symbols:
PTK2
Immunogen:
Recombinant protein corresponding to amino acid residues 853-1052 from theC-terminal region of human FAK.
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Clone:
__
Conjugate:
Unconjugated
Gene:
PTK2
Gene Alias:
CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel\CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
14083, 25614, 5747
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phosphotyrosine
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.08% sodium azide
Gene Accession No.: __
Gene Symbols: __
Immunogen: Keyhole limpet hemocyanin coupled with equal amounts of phosphotyrosine, glycine, and alanine.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chemical
Product Type: Antibody
Isotype: IgG2b
Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone: pY20
Conjugate: Unconjugated
Gene: __
Gene Alias: Phosphotyrosine; pTyr; pY
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phosphotyrosine
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.08% sodium azide
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Keyhole limpet hemocyanin coupled with equal amounts of phosphotyrosine, glycine, and alanine.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Chemical
Product Type:
Antibody
Isotype:
IgG2b
Applications:
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
pY20
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
Phosphotyrosine; pTyr; pY
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: EIF2S1
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.1% sodium azide; pH 7.4
Gene Accession No.: P05198, P68101, Q6ZWX6
Gene Symbols: EIF2S1
Immunogen: Recombinant human eIF-2-alpha.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
Clone: EIF2-alpha
Conjugate: Unconjugated
Gene: EIF2S1
Gene Alias: 0910001O23Rik; 2410026C18Rik; 35kDa; EIF2; EIF-2; eIF2 alpha; eIF2 alpha subunit; EIF2A; eIF-2A; eIF2alpha; EIF-2alpha; eIF-2-alpha; EIF2S1; eif2s1b; Eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit 1b; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 alpha b; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A; fb19d01; translation initiation factor subunit; wu:fb19d01
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 13665, 1965, 54318
Content And Storage: -20°C
Form: Liquid
Antigen:
EIF2S1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.1% sodium azide; pH 7.4
Gene Accession No.:
P05198, P68101, Q6ZWX6
Gene Symbols:
EIF2S1
Immunogen:
Recombinant human eIF-2-alpha.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
Clone:
EIF2-alpha
Conjugate:
Unconjugated
Gene:
EIF2S1
Gene Alias:
0910001O23Rik; 2410026C18Rik; 35kDa; EIF2; EIF-2; eIF2 alpha; eIF2 alpha subunit; EIF2A; eIF-2A; eIF2alpha; EIF-2alpha; eIF-2-alpha; EIF2S1; eif2s1b; Eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit 1b; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 alpha b; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A; fb19d01; translation initiation factor subunit; wu:fb19d01
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
13665, 1965, 54318
Content And Storage:
-20°C
Form:
Liquid