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AMPA6512

HIF-1 beta Monoclonal Antibody (H1beta234), Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 AMPA6512-Each-of-1 In Stock ₹ 45,218.46

AMPA6512 - Each of 1

₹ 45,218.46

In Stock

Quantity

1

Base Price: ₹ 45,218.46

GST (18%): ₹ 8,139.323

Total Price: ₹ 53,357.783

Antigen

HIF-1 beta

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.05% sodium azide

Gene Accession No.

P27540, P41739, P53762, Q9BE97

Gene Symbols

ARNT

Immunogen

Fusion protein containing residues 496-789 of human ARNT.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat

Product Type

Antibody

Isotype

IgG1 κ

Applications

ChIP Assay, ChIP sequencing (ChIP-seq), Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone

H1beta234

Conjugate

Unconjugated

Gene

ARNT

Gene Alias

AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

11863, 25242, 281010, 405, 443285

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • Suggested positive control: antigen standard for ARNT (transient overexpression lysate)
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
  • This occurs as a posttranslational modification by prolyl hydroxylation
  • HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
  • Both subunits are constantly translated
  • However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
  • Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
  • Therefore, the concentration of HIF-1 alpha increases in the cell
  • In contrast, HIF-1 beta remains stable under either condition
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
  • This occurs as a posttranslational modification by prolyl hydroxylation
  • HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
  • Both subunits are constantly translated
  • However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
  • Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
  • Therefore, the concentration of HIF-1 alpha increases in the cell
  • In contrast, HIF-1 beta remains stable under either condition
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.

Compare Similar Items

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Thermo Scientific

AMPA6512

--

Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing residues 496-789 of human ARNT.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
H1beta234
Conjugate:
Unconjugated
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

Thermo Scientific

AMPA6517

--

Antigen:
HIF1A
Classification:
Monoclonal
Concentration:
1.5 mg/mL
Formulation:
PBS with 0.05% sodium azide
Gene Accession No.:
Q16665
Gene Symbols:
HIF1A
Immunogen:
Fusion protein containing residues 432-528 of human HIF-1 alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Non-human Primate
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Western Blot
Clone:
H1alpha 67-7
Conjugate:
Unconjugated
Gene:
HIF1A
Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L home
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
3091
Content And Storage:
4° C, do not freeze
Form:
Liquid

Img

Thermo Scientific

AMPA6519

--

Antigen:
HIF-2 alpha
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Formulation:
PBS with 1% BSA and 0.05% sodium azide
Gene Accession No.:
P97481, Q99814, Q9JHS1
Gene Symbols:
EPAS1
Immunogen:
Synthetic peptid corresponding to residues 535-631 of human HIF-2 alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Hamster, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
ChIP Assay, ELISA, Flow Cytometry, Gel Shift, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
ep190b
Conjugate:
Unconjugated
Gene:
EPAS1
Gene Alias:
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
100771160, 13819, 2034, 282711, 29452
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid

Img

Thermo Scientific

AMPA6541

--

Antigen:
RAD51C
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.:
O43502, Q924H5
Gene Symbols:
RAD51C
Immunogen:
His-tagged human Rad 51C, over-expressed in E. coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Yeast
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
2H11/6
Conjugate:
Unconjugated
Gene:
RAD51C
Gene Alias:
BROVCA3; DNA repair protein RAD51 homolog 3; FANCO; MGC104277; R51H3; RAD51 homolog C; RAD51 paralog C; RAD51C; RAD51L2; RAD51-like protein 2; RGD1563765; yeast RAD51 homolog 3
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
114714, 5889
Content And Storage:
4° C, do not freeze
Form:
Liquid