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AMPA6512

HIF-1 beta Monoclonal Antibody (H1beta234), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 AMPA6512-Each-of-1 In Stock ₹ 47,036.50

AMPA6512 - Each of 1

₹ 47,036.50

In Stock

Quantity

1

Base Price: ₹ 47,036.50

GST (18%): ₹ 8,466.57

Total Price: ₹ 55,503.07

Antigen

HIF-1 beta

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.05% sodium azide

Gene Accession No.

P27540, P41739, P53762, Q9BE97

Gene Symbols

ARNT

Immunogen

Fusion protein containing residues 496-789 of human ARNT.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat

Product Type

Antibody

Isotype

IgG1 κ

Applications

ChIP Assay, ChIP sequencing (ChIP-seq), Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone

H1beta234

Conjugate

Unconjugated

Gene

ARNT

Gene Alias

AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

11863, 25242, 281010, 405, 443285

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • Suggested positive control: antigen standard for ARNT (transient overexpression lysate)
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
  • This occurs as a posttranslational modification by prolyl hydroxylation
  • HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
  • Both subunits are constantly translated
  • However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
  • Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
  • Therefore, the concentration of HIF-1 alpha increases in the cell
  • In contrast, HIF-1 beta remains stable under either condition
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
  • HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
  • This occurs as a posttranslational modification by prolyl hydroxylation
  • HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
  • Both subunits are constantly translated
  • However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
  • Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
  • Therefore, the concentration of HIF-1 alpha increases in the cell
  • In contrast, HIF-1 beta remains stable under either condition
  • HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
  • Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.