AMPA6854

Survivin Monoclonal Antibody (32.1), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 AMPA6854-Each-of-1 In Stock ₹ 45,731.82

AMPA6854 - Each of 1

₹ 45,731.82

In Stock

Quantity

1

Base Price: ₹ 45,731.82

GST (18%): ₹ 8,231.728

Total Price: ₹ 53,963.548

Antigen

Survivin

Classification

Monoclonal

Concentration

1.9 mg/mL

Formulation

PBS with 0.02% sodium azide

Gene Accession No.

O15392

Gene Symbols

Birc5

Immunogen

Recombinant human survivin, full-length

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Hamster, Human

Product Type

Antibody

Isotype

IgG1 κ

Applications

ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone

32.1

Conjugate

Unconjugated

Gene

Birc5

Gene Alias

AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

100689366, 332

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • The PA1-46190 immunogen is a synthetic peptide made to the human TAZ protein, selected for its lack of homology to the YAP protein
  • Suggested positive control: HeLa nuclear extract, antigen standard for BIRC5 (transient overexpression lysate)
  • Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family
  • The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues
  • IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain
  • The encoded proteins also lack a C-terminus RING finger domain
  • Gene expression is high during fetal development and in most tumors yet low in adult tissues
  • Antisense transcripts are involved in the regulation of survivin’s gene expression
  • Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner
  • At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics
  • Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis
  • Survivin may counteract a default induction of apoptosis in G2/M phase
  • Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury
  • Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein)
  • Survivin might affect regulation of neural cell proliferative responses after brain injury
  • At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined
  • The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

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AMPA6854

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Antigen:
Survivin

Classification:
Monoclonal

Concentration:
1.9 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
O15392

Gene Symbols:
Birc5

Immunogen:
Recombinant human survivin, full-length

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Hamster, Human

Product Type:
Antibody

Isotype:
IgG1 κ

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
32.1

Conjugate:
Unconjugated

Gene:
Birc5

Gene Alias:
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
100689366, 332

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

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AMPA6874

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Antigen:
Blimp-1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
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Gene Symbols:
PRDM1

Immunogen:
A fragment of the mouse Blimp-1 (residues 199-409).

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Porcine

Product Type:
Antibody

Isotype:
IgG1

Applications:
ChIP Assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
3H2-E8

Conjugate:
Unconjugated

Gene:
PRDM1

Gene Alias:
B lymphocyte-induced maturation protein 1; b2b1765Clo; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; Blimp1; BLIMP-1; B-lymphocyte-induced maturation protein 1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR/SET domain 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; Prdm1; RP1-134E15.1; ZNFPR1A1

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
100154284, 12142, 639

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

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Antigen:
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Classification:
Monoclonal

Concentration:
1.0 mg/mL

Formulation:
PBS with 0.1% sodium azide

Gene Accession No.:
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Gene Symbols:
__

Immunogen:
Ethenoadenosine.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Chemical

Product Type:
Antibody

Isotype:
IgG2 λ

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
1G4

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
C12H13N5O4; N6-Ethenoadenosine

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

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Antigen:
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Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.1% sodium azide

Gene Accession No.:
P01830, P01831

Gene Symbols:
Thy1

Immunogen:
Full length protein (Rat).

Quantity:
250 μg

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Isotype:
IgG1

Applications:
Affinity Purification, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunomicroscopy

Clone:
OX-7

Conjugate:
Unconjugated

Gene:
Thy1

Gene Alias:
CD7; CD90; CDw90; FLJ33325; membrane glycoprotein; T25; Thy 1.2; THY1; Thy-1; Thy-1 antigen; Thy-1 cell surface antigen; thy-1 glycoprotein; thy-1 membrane glycoprotein; Thy-1 protein; Thy-1 T-cell antigen; Thy1.1; Thy1.2; Thy-1.2; thymus cell antigen 1, theta; Thymus cell surface antigen

Host Species:
Mouse

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
21838, 24832

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid