CD49d (Integrin α4 chain) Mouse anti-Human, PE, Clone: L25, BD

Description

• CD49d (Anti–VLA-α4), clone L25, is derived from the fusion of mouse Sp2/0 cells with popliteal lymph node cells from a BALB/c mouse immunized with a CD8 + T-cell line
• CD49d (Anti–VLA-α4) recognizes the 150-kilodalton (kd) α chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules
• VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and β subunits and is involved in cell–cell and cell–extracellular matrix interactions
• The β chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein
• The CD29 antigen, also known as the β1 subunit, is common to the VLA family of integrins
• When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin
• When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1)
• The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion
• The CD49d antigen, when associated with the β7 integrin, forms a lymphocyte homing receptor for Peyer's patch, binding to the mucosal vascular addressin MAdCAM-1
• The CD49d antigen is also involved in CD3-dependent CD4 + T-lymphocyte activation via its interaction with fibronectin.