CD4 Rat anti-Mouse, Unlabeled, Clone: H129.19, BD

Description

• The H129.19 antibody reacts with the CD4 (L3T4) differentiation antigen expressed on thymocytes, a subpopulation of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells), and a subset of NK-T cells of all mouse strains tested
• CD4 has also been detected on pluirpotent hematopoietic stem cells, bone marrow myeloid precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells
• CD4 is expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm
• CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells
• It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine lck
• H129.19 mAb blocks binding of the anti-mouse CD4 mAbs Gk1.5 (Cat
• No
• 557307/553729) and RM4-5 (Cat
• No
• 553046/553047), but not RM4-4 (Cat
• No
• 553055) antibody
• mAb H129.19 inhibits various responses of T helper cells to antigenic or mitogenic stimuli
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.