CD184 Rat anti-Human, Unlabeled, Clone: 1D9, BD

Description

• The monoclonal antibody 1D9 reacts with the human CD184 which is also known as CXC chemokine receptor, CXCR4
• CXCR4 (previously known as fusin, LESTR and HUMSTR), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokines, SDF-1/CXCL12
• CXCR4 was widely expressed by hematopoietic and non-hematopoietic cell types including PMN, monocytes, T cells, B cells, CD34+ progenitor cells, endothelial cells, neurons and astrocytes
• The human CXCR4 is used by T-tropic HIV-1 as a co-receptor for viral entry
• The human CXCR4 gene has been mapped to chromosome 2q21
• The immunogen used to generate 1D9 hybridoma was human CXCR4 fusion protein
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.