CD124 Mouse anti-Human, PE, Clone: HIL4R-M57, BD

Description

• The hIL4R-M57 antibody specifically binds to the α subunit (IL-4R α ) of the human Interleukin-4 Receptor complex which is also known as CD124
• The human IL-4R α , also known as B cell stimulatory factor 1 receptor (BSF-1 receptor), is a 140 kDa transmembrane glycoprotein that is expressed by B and T lymphocytes and a variety of other hematopoietic and non-hematopoietic cells and cell lines
• The cell surface IL-4R α chain binds IL-4 with high affinity and associates with either the common γchain (IL-4R α / γα exists in soluble form in biological fluids
• In contrast to mice, in humans no distinct mRNA coding for sIL-4R has been described, suggested that human sIL4-R is exclusively produced by proteolytic cleavage of the cell surface receptor
• The serum levels of soluble IL-4R α appear to elevate in pathological situations such as allergy and parasitic infections
• Depending on the ratios of IL-4 and sIL-4R α present in the local milieu, the sIL-4R α may augment or antagonize the activities of IL-4
• The immunogen used to generate the hIL4R-M57 hybridoma was soluble human IL-4R
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.