CD28 Hamster anti-Mouse, Biotin, Clone: 37.51, BD

Description

• The 37.51 antibody reacts with CD28, which is expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T cells, and at even lower density on NK cells
• The expression of CD28, in splenocytes and thymocytes,has been reported to increase after activation
• CD28 transcripts are found in mast cells, and cell-surface expression of CD28 is induced upon maturation or activation of mast cells
• It has been reported that CD28 is not expressed on some populations of intraepithelial T lymphocytes
• CD28 is a costimulatory receptor; its ligands include CD80 (B7-1) and CD86 (B7-2)
• The 37.51 mAb augments proliferation and cytokine production by activated T and NK cells and can provide a costimulatory signal for CTL induction
• There is considerable evidence that CD28 is a costimulatory receptor involved in many, but not all, T cell-dependent immune responses
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.