CD122 Rat anti-Mouse, FITC, Clone: TM- Tests1, BD

Description

• The TM-β1 antibody reacts with the 90-100-kDa β chain shared by the IL-2 and IL-15 receptors (IL-2Rβ, CD122)
• In the periphery, CD122 is expressed on CD8+ T lymphocytes, NK cells, NK-T cells, dendritic epidermal T cells, subsets of intraepithelial lymphocytes, and macrophages
• Small subsets of fetal and adult thymocytes constitutively express CD122
• CD122+ cells in the bone marrow include committed NK-cell progenitors
• IL-2Rβ expression is upregulated by IL-2
• CD122 is a transmembrane glycoprotein of the hematopoietin receptor superfamily which can combine with CD132 (γc) alone or CD132 plus CD25 (IL-2Rα) to form intermediate or high-affinity IL-2 receptor complexes, respectively
• The β chain of these complexes, CD122, is involved in signal transduction and immunoregulation
• The TM- β 1 antibody blocks high affinity binding of IL-2 or IL-15 to IL-2R β
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.