BDB555312
Ly-49D Rat anti-Mouse, Unlabeled, Clone: 4E5, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB555312-Each-of-1 | In Stock | ₹ 30,288.24 |
BDB555312 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,288.24
GST (18%): ₹ 5,451.883
Total Price: ₹ 35,740.123
Antigen
Ly-49D
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Not reported
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
4.00E+05
Conjugate
Unconjugated
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Related Products
Description
- The 4E5 antibody reacts with Ly-49D, which is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He (at a very low frequency), and SJL, but not DBA/2, AKR, CBA/J, or BALB/c mice
- Unlike Ly-49D antigen has not been betected on NK-1.1+ (or DX5+) T cells
- In 129/J mice, the 4E5 antibody cross-reacts with Ly-49O, Ly-49R, and Ly-49V
- The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate-recognition domains, which bind to MHC class I alloantigens
- The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor homodimers
- Ly-49D weakly binds to MHC class I antigens of the k halpotype, and Ly-49D+ IL-2-activated NK cells lyse target cells expressing H-2[a], H-2[b], H-2[d], H-2[k], H-2[p], H-2[q], and H-2[s] and the CHO (Chinese hamster ovary) cell line
- Ly-49D+ cells mediate allogenic resistance to H-2d bone marrow transplantation
- In vitro studies suggest that the Ly-49D receptor mediates activation of NK-cell cytolytic activity via tyrosine phosphorylation of their ITIMs (Immunoreceptor Tyrosine-based Inhibitory Motifs)
- Molecular differences between the Ly-49D stimulatory receptor and the inhibitory members of the Ly-49 family include the absence of an ITIM in Ly-49D, the lack of phosphorylation of Ly-49D in activated NK cells, and the association of a novel tyrosine-phosphorylated protein (pp16) with Ly-49D in activated NK cells
- Ly-49O and Ly-49V are closely related to Ly-49A[B6] and, like Ly-49A, have ITIM domains
- Ly-49O- and Ly-49V-transfected 293T (human kidney epithelial) cells bind tetramers of H-2D[b], D[b], D[k], and L[d]
- In addition, the Ly-49V-transfected cells also bind K[b], K[d], and K[k]
- Ly-49R is closely related to Ly-49D[B6] and is putative activating receptor due to its lack of an ITIM domain
- Ly-49R-transfected 293T cells bind soluble tetramers of H-2D[b], D[d], D[k], and L[d]
- Flow Cytometry, Immunoprecipitation
Compare Similar Items
Show Difference
Antigen: Ly-49D
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Not reported
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: 4.00E+05
Conjugate: Unconjugated
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Ly-49D
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Not reported
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
4.00E+05
Conjugate:
Unconjugated
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: CD74
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: ATL mouse lymphocytes and B10A mouse-derived CH1 B-cell lymphoma
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: IN-1
Conjugate: Unconjugated
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
CD74
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
ATL mouse lymphocytes and B10A mouse-derived CH1 B-cell lymphoma
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
IN-1
Conjugate:
Unconjugated
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: CD74
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: ATL mouse lymphocytes and B10A mouse-derived CH1 B-cell lymphoma
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: IN-1
Conjugate: FITC
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD74
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
ATL mouse lymphocytes and B10A mouse-derived CH1 B-cell lymphoma
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
IN-1
Conjugate:
FITC
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD2
Classification: Monoclonal
Concentration: 1.0mg/mL
Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen: Human Phytohemagglutinin-treated Lymphoblasts
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Human
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: RPA-2.10
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
CD2
Classification:
Monoclonal
Concentration:
1.0mg/mL
Formulation:
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen:
Human Phytohemagglutinin-treated Lymphoblasts
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
RPA-2.10
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C