mGluR17α Mouse anti-Rat, Unlabeled, Clone: G209-488, BD

Description

• Glutamate is a major excitatory neurotransmitter in mammalian brain
• Glutamatergic neurotransmission is mediated by a family of glutamate receptors that can be grouped into two classes, ionotropic (GluR) and metabotropic (mGluR) receptors
• The metabotropic glutamate receptors consist of at least seven subtypes that can be divided into three groups on the basis of their sequence similarities, intracellular second messengers, and agonist selectivity
• These groups are 1) mGluR1 and mGluR5; 2) mGluR2 and mGluR3; and 3) mGluR4, mGluR6 and mGluR7
• mGluR1 and mGluR5 are coupled to the inositol phosphate/Ca[2+] signal transduction pathway, whereas the other five receptors are linked to the inhibition of the cAMP cascade
• mRNA analysis shows that the seven receptors have different expression patterns in the central nervous system
• For example, the highest level of mGluR1 mRNA expression is found in the cerebellar Purkinje cells
• mGluR7 mRNA is moderately expressed in these cells, whereas the mRNA of the other five mGluRs is barely detectable
• Three splice variants have been described for mGluR1; mGluR1α (145kDa), mGluR1β (97kDa) and mGluR1c (97kDa)
• G209-488 recognizes rat mGluR1α
• It does not cross-react with the other splice variants of mGluR1, mGluR1β and mGluR1c
• Additionally G209-488 does not crossreact with mGluR5, the most closely related mGluR family member
• The antibody was characterized by western blot analysis using rat brain membranes, and by immunohistochemical analysis using frozen rat brain tissue sections
• A full length recombinant rat mGluR1 fusion protein was used as immunogen
• Host Species: Mouse Clone: G209-488 Isotype: IgG1 Species Reactivity: Rat Immunogen: Recombinant Rat mGluR1 Fusion Protein Immunohistochemistry (Frozen), Western Blotting