CD19 Mouse anti-Human, APC-Cy7, Clone: SJ25C1, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size	SKU	Availability	Price
Each of 1	BDB557791-Each-of-1	In Stock	₹ 31,828.32

BDB557791 - Each of 1

₹ 31,828.32

In Stock

Quantity

Base Price: ₹ 31,828.32

GST (18%): ₹ 5,729.098

Total Price: ₹ 37,557.418

Antigen

CD19

Classification

Monoclonal

Conjugate

APC-Cyanine7

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

SJ25C1

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Human NALM1 + NALM16 cells

Quantity

100 Tests

Research Discipline

Immunology

Target Species

Human

Isotype

IgG1 κ

Description

The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen
CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages
Terminally differentiated plasma cells do not express CD19
On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation
Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery
B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice
Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery
CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance
CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.