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BDB557814

Stat3 (pY705) Mouse, Alexa Fluor 488, Clone: 4/P-STAT3, BD

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB557814-Each-of-1 In Stock ₹ 28,257.50

BDB557814 - Each of 1

₹ 28,257.50

In Stock

Quantity

1

Base Price: ₹ 28,257.50

GST (18%): ₹ 5,086.35

Total Price: ₹ 33,343.85

Antigen

Stat3 (pY705)

Classification

Monoclonal

Conjugate

Alexa Fluor 488

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

4/P-STAT3

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Phosphorylated Human Stat3 Peptide

Quantity

50 Tests

Research Discipline

Cell Biology

Target Species

Human, Mouse

Isotype

IgG2a κ

Description

  • Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors
  • Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation
  • Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes
  • Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner
  • Stat3 is a 92kDa protein that is activated as a DNA- binding protein through cytokines, such as IL-6, and growth factors, such as EGF
  • Stat3 activation occurs via tyrosine phosphorylation at Y705
  • Tyrosine phosphorylation in response to cytokine stimulation is generally mediated by JAK1
  • Upon activation, Stat3 dimerizes, translocates to the nucleus and binds DNA response elements, thereby regulating gene expression
  • It has been reported that Stat3 binds to DNA as a homodimer, but it is also capable of binding as a heterodimer with Stat1
  • In addition to tyrosine phosphorylation, Stat3 is also phosphorylated at S727 via the MAPK pathway
  • Stat3 is widely expressed and can bind to the sis-inducible element (SIE) site from the c-fos promoter
  • This site is similar to the GAS element that is present in IFN-γ induced genes
  • Thus, phosphorylation of Y705 in Stat3 occurs in response to growth factors and cytokines, and is essential for normal transcription activity
  • The 4/P-STAT3 monoclonal antibody recognizes the phosphorylated Y705 of Stat3
  • This antibody is routinely tested by flow cytometric analysis
  • Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
  • Host Species: Mouse Clone: 4/P-STAT3 Isotype: IgG2a, κ Cross Reactivity: Human, Mouse Flow Cytometry, Intracellular Staining, Western Blotting

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BDB557814

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Antigen:
Stat3 (pY705)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
4/P-STAT3
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human Stat3 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG2a κ

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Antigen:
Stat3 (pY705)
Classification:
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Host Species:
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Purification Method:
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Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
4/P-STAT3
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
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