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BDB558085

Stat3 (pS727) Mouse, Alexa Fluor 488, Clone: 49/P-STAT3, BD

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB558085-Each-of-1 In Stock ₹ 27,165.30

BDB558085 - Each of 1

₹ 27,165.30

In Stock

Quantity

1

Base Price: ₹ 27,165.30

GST (18%): ₹ 4,889.754

Total Price: ₹ 32,055.054

Antigen

Stat3 (pS727)

Classification

Monoclonal

Conjugate

Alexa Fluor 488

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

49/P-STAT3

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Phosphorylated Human Stat3

Quantity

50 Tests

Research Discipline

Cell Biology

Target Species

Human, Mouse, Rat

Isotype

IgG1

Description

  • The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription
  • Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6
  • Stat3 is a 92kDa protein that is activated as a DNA binding protein through cytokines, such as IL-6, and growth factors, such as EGF
  • Stat3 is phophorylated at serine 727 (S727) via the MAPK pathway
  • The S727 residue is located at a conserved Pro-X-Ser-Pro sequence, which is recognized by the protein kinase ERK
  • Activation through the S727 residue is thought to lead to initiation of transcription
  • Upon activation, Stat3 dimerizes, translocates to the nucleus, and binds DNA response elements thereby regulating gene expression
  • It appears that Stat3 binds to DNA as a homodimer, but it is also capable of binding as a heterodimer with Stat1
  • In addition to serine phosphorylation, Stat3 is also phosphorylated at tyrosine 705 by JAK1 in response to cytokine stimulation
  • Stat3 is widely expressed and can bind to the sis-inducible element (SIE) site from the c-fos promoter
  • This site is similar to the GAS element that is present in IFN-γ-induced genes
  • Thus, phosphorylation of S727 in Stat3 occurs in response to growth factors and cytokines, and is essential for normal transcription activity
  • The 49/p-Stat3 monoclonal antibody recognizes the S727-phosphorylated form of Stat3 (isoform 1)
  • The fluorochrome-conjugated formats have been evaluated using a human model system
  • However, the unconjugated form of this antibody (Mfr
  • No.612542 or 612543) is also effective for western blot analysis of human, mouse, and rat tissue
  • Host Species: Mouse Clone: 49 Isotype: IgG1 Species Reactivity: Human Immunogen: Phosphorylated Human Stat3 Flow Cytometry, Intracellular Staining

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Antigen:
Stat3 (pS727)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
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Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human Stat3
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1

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