BDB558360
CD140b (pY857) Mouse, Unlabeled, Clone: J24-425, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558360-Each-of-1 | In Stock | ₹ 48,426.96 |
BDB558360 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,426.96
GST (18%): ₹ 8,716.853
Total Price: ₹ 57,143.813
Antigen
CD140b (pY857)
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Phosphorylated Human PDGFRβ
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG1 κ
Applications
Western Blot
Clone
J24-425
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Description
- Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchy mal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase
- PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) polypeptides
- Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs
- Ligand binding indu ces dimerization and activation of the receptor
- Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated
- PDGFR localizes primarily to membrane invaginations termed caveolae , compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3'-kinase, Src, and phospholipase C-γ
- The J24-425 monoclonal antibody recognizes the phosphorylated tyrosine 857 (pY857) in the tyrosine kinase domain 2 of CD140b , which is required for maximal receptor kinase activity
- The orthologous phosphorylation site in mouse PDGFRβ is Y856.
Compare Similar Items
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Antigen: CD140b (pY857)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human PDGFRβ
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human, Mouse
Isotype: IgG1 κ
Applications: Western Blot
Clone: J24-425
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
CD140b (pY857)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human PDGFRβ
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
J24-425
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: LAT (pY226)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human LAT Peptide
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1 κ
Applications: Western Blot
Clone: J96-1238.58.93
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
LAT (pY226)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human LAT Peptide
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
J96-1238.58.93
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: BLNK (pY84)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human BLNK Peptide
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human, Mouse
Isotype: IgG2b κ
Applications: Western Blot
Clone: J117-1278
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
BLNK (pY84)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human BLNK Peptide
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG2b κ
Applications:
Western Blot
Clone:
J117-1278
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: CD328
Classification: Monoclonal
Concentration: __
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Recombinant Siglec-7
Quantity: 100 Tests
Research Discipline: Immunology
Target Species: Human
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: F023-420
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD328
Classification:
Monoclonal
Concentration:
__
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Recombinant Siglec-7
Quantity:
100 Tests
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
F023-420
Conjugate:
PE
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.