BDB558378
IRS-1 (pY896) Mouse anti-Human, Unlabeled, Clone: K9-211, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558378-Each-of-1 | In Stock | ₹ 48,426.96 |
BDB558378 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,426.96
GST (18%): ₹ 8,716.853
Total Price: ₹ 57,143.813
Antigen
IRS-1 (pY896)
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Phosphorylated Human IRS-1 Peptide
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG2a κ
Applications
Western Blot
Clone
K9-211
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Related Products
Description
- The IRS (Insulin Receptor Substrate) proteins IRS-1, IRS-2, IRS-3, and IRS-4 are major substrates of the insulin receptor and the insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases
- IRS proteins contain an N-terminal pleckstrin homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and multiple tyrosine phosphorylation sites in the C-terminus
- The IRS-1 protein is widely expressed and, along with IRS-2, mediates somatic growth and carbohydrate metabolic responses to insulin
- Following insulin receptor ligation, IRS-1 binds to the juxtamembrane region of the receptor via the PH and PTB domains and is tyrosine phosphorylated, which facilitates its interaction with SH2 domain-containing signaling proteins
- Specifically, the phosphorylated tyrosine 896 (pY896) of human IRS-1 is a major binding site for the GRB2 (Growth-factor Receptor-Bound protein 2) adaptor protein
- After IRS-1 activation, negative and positive feedback regulates dephosphorylation of its tyrosine sites, which ultimately regulates the magnitude and/or duration of the downstream pleiotropic responses to insulin and IGF-1
- The K9-211 monoclonal antibody recognizes pY896 of human IRS-1
- The orthologous phosphorylation sites of mouse and rat IRS-1 are Y891 and Y895, respectively
- Western Blotting
Compare Similar Items
Show Difference
Antigen: IRS-1 (pY896)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human IRS-1 Peptide
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2a κ
Applications: Western Blot
Clone: K9-211
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
IRS-1 (pY896)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human IRS-1 Peptide
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Western Blot
Clone:
K9-211
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: EGF Receptor (pY845)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human EGF Receptor Peptide
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Applications: Western Blot
Clone: 12A3
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
EGF Receptor (pY845)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human EGF Receptor Peptide
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
12A3
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Rb (pS780)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human Rb
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1 κ
Applications: Western Blot
Clone: J146-35
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Rb (pS780)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human Rb
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
J146-35
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: SLP-76 (pY113)
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated Human SLP-76 Peptide
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1 κ
Applications: Western Blot
Clone: J80-373
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
SLP-76 (pY113)
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human SLP-76 Peptide
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
J80-373
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C