BDB558419
CD140b (pY1021) Mouse, Alexa Fluor 488, Clone: J105-412, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558419-Each-of-1 | In Stock | ₹ 25,154.64 |
BDB558419 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,154.64
GST (18%): ₹ 4,527.835
Total Price: ₹ 29,682.475
Antigen
CD140b (pY1021)
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
J105-412
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human PDGFRβ (pY1021)
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG1 κ
Description
- Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase
- PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) polypeptides
- Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs
- Ligand binding induces dimerization and activation of the receptor
- Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated
- PDGFR localizes primarily to membrane invagin ations termed caveolae, compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3'-kinase, Src, and phospholipase C-γ(PLC-γ)
- The J105-412 monoclonal antibody recognizes the phosphorylated tyrosine 1021 (pY1021 ) in the C-terminal noncatalytic region of CD140b, which interacts primarily with PLC-γ
- The orthologous phosphorylation site in mouse PDGFRβ is Y1020.
Compare Similar Items
Show Difference
Antigen: CD140b (pY1021)
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: J105-412
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human PDGFRβ (pY1021)
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse
Isotype: IgG1 κ
Antigen:
CD140b (pY1021)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
J105-412
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human PDGFRβ (pY1021)
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG1 κ
Antigen: __
Classification: __
Conjugate: __
Host Species: __
Purification Method: __
Regulatory Status: __
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Research Discipline: __
Target Species: __
Isotype: __
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__
Classification:
__
Conjugate:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
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__
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Antigen: NF-κB p65 (pS529)
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Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Applications: Flow Cytometry
Clone: K10-895.12.50
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human NF-κB p65 Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human
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Antigen:
NF-κB p65 (pS529)
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Mouse
Purification Method:
Affinity Purified
Regulatory Status:
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Primary or Secondary:
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Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
K10-895.12.50
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human NF-κB p65 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
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Isotype:
IgG2b κ