BDB558429
CD140b (pY857) Mouse, PE, Clone: J24-618, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558429-Each-of-1 | In Stock | ₹ 27,036.96 |
BDB558429 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,036.96
GST (18%): ₹ 4,866.653
Total Price: ₹ 31,903.613
Antigen
CD140b (pY857)
Classification
Monoclonal
Conjugate
PE
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
J24-618
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human PDGFRβ Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG1 κ
Description
- Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase
- PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) polypeptides
- Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs
- Ligand binding induces dimerization and activation of the receptor
- Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated
- PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3'-kinase, Src, and phospholipase C-γ
- The J24-618 monoclonal antibody recognizes the phosphorylated tyrosine 857 (pY857) in the tyrosine kinase domain 2 of CD140b, which is required for maximal receptor kinase activity
- The orthologous phosphorylation site in mouse PDGFRβ is Y856.
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Show Difference
Antigen: CD140b (pY857)
Classification: Monoclonal
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: J24-618
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human PDGFRβ Peptide
Quantity: 50 Tests
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Antigen:
CD140b (pY857)
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Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
J24-618
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human PDGFRβ Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
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Human, Mouse
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Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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