BDB558498
PLC-γ2 (pY759) Mouse, Alexa Fluor 647, Clone: K86-689.37, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558498-Each-of-1 | In Stock | ₹ 27,165.30 |
BDB558498 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,165.30
GST (18%): ₹ 4,889.754
Total Price: ₹ 32,055.054
Antigen
PLC-γ2 (pY759)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
K86-689.37
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human PLC-γ2 Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG1 κ
Description
- Description The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol
- The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C
- Within the PLC family, PLC-γ is the only member that contains SH2 and SH3 domains
- These domains enable it to interact with protein tyrosine kinases and become enzymatically activated via phosphorylation
- It exists as two isoforms: PLC-γ1, which is ubiquitously expressed, and PLC-γ2, which is found primarily in the hematopoietic system
- PLC-γ2-null mice exhibit impaired B lymphocyte maturation and defects in Fc receptor functions
- Phosphorylation of PLC-γ2 at tyrosines 753 and 759 (Y759) is required for activation of PLC-γ2 enzyme activity
- PLC-γ2 phosphorylation at Y759 can be induced by stimulation of the B cell receptor in Ramos cells, the collagen receptor in platelets, and the T cell receptor in Jurkat cells, and it occurs downstream of Btk and BLNK in the signaling cascade of activated B cells
- The K86-689.37.73 antibody recognizes PLC-γ2 phosphorylated at Y759 in the SH2-SH3 linker region
- Intracellular Staining
Compare Similar Items
Show Difference
Antigen: PLC-γ2 (pY759)
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: K86-689.37
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human PLC-γ2 Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Antigen:
PLC-γ2 (pY759)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
K86-689.37
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human PLC-γ2 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Antigen: IL-21
Classification: Monoclonal
Conjugate: Biotin
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: ELISA
Clone: I76-539
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Human IL-21 Recombinant Protein
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Human
Isotype: IgG1 κ
Antigen:
IL-21
Classification:
Monoclonal
Conjugate:
Biotin
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
ELISA
Clone:
I76-539
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Human IL-21 Recombinant Protein
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG1 κ
Antigen: IL-21
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Applications: ELISA
Clone: J148-1134
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Human IL-21 Recombinant Protein
Quantity: 0.5 mg
Research Discipline: Immunology
Target Species: Human
Isotype: IgG1 κ
Antigen:
IL-21
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Applications:
ELISA
Clone:
J148-1134
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Human IL-21 Recombinant Protein
Quantity:
0.5 mg
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG1 κ
Antigen: PLC-γ2 (pY759)
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: K86-689.37
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human PLC-γ2 Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Antigen:
PLC-γ2 (pY759)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
K86-689.37
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human PLC-γ2 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ