BDB558510

Zap70 (pY292) Mouse anti-Human, PE, Clone: J34-602, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB558510-Each-of-1 In Stock ₹ 29,560.98

BDB558510 - Each of 1

₹ 29,560.98

In Stock

Quantity

1

Base Price: ₹ 29,560.98

GST (18%): ₹ 5,320.976

Total Price: ₹ 34,881.956

Antigen

Zap70 (pY292)

Classification

Monoclonal

Conjugate

PE

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Phosphorylated Human ZAP70 Peptide

Quantity

50 Tests

Research Discipline

Cell Biology

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

J34-602

Description

ZAP-70 (pY292)

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • The 70kDa ζ chain-associated protein (ZAP70) is a Syk-family protein tyrosine kinase (PTK) that associates with the ζ subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation
  • ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus
  • TCR-mediated Lck activity leads to phosphorylation of ZAP70 on Tyrosine 493 in the regulatory loop of the PTK domain leading to upregulation of ZAP70 kinase activity
  • Tyrosine 292 (Y292), in the linker region between the SH2 and PTK domains, is autophosphorylated by the activated PTK domain
  • By binding with c-Cbl, the phosphorylated Y292 can down-regulate TCR signaling
  • The J34-602 antibody recognizes ZAP70 phosphorylated at Y292
  • Intracellular Staining

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Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

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Phosphorylated Human ZAP70 Peptide

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