BDB558545
FAK (pS910) Mouse, Alexa Fluor 647, Clone: K73-480, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558545-Each-of-1 | In Stock | ₹ 26,166.00 |
BDB558545 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,166.00
GST (18%): ₹ 4,709.88
Total Price: ₹ 30,875.88
Antigen
FAK (pS910)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
K73-480
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human FAK Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG2b κ
Description
- Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that associates with integrins in focal adhesions
- Its cellular localization is directed by a 125-amino acid sequence at the C terminus called the “Focal Adhesion Targeting” (FAT) domain, and the phosphorylation state of serine 910 (S910) in the FAT domain may regulate the assembly of focal adhesions
- Furthermore, the binding of extracellular matrix ligands to integrins triggers tyrosine phosphorylations near FAK's kinase domain that increase its kinase activity, and additional tyrosine phosphorylations near proline-rich motifs create binding sites for the SH2 domains of various adaptor proteins
- FAK's ability to bind numerous structural and signaling proteins via a variety of interactions regulates FAK's targeting to focal adhesions, modulates its kinase activity, and initiates intracellular signaling cascades
- Thus, studies suggest that FAK may integrate cellular events controlling cell motility, growth, and invasiveness
- The K73-480 monoclonal antibody recognizes the phosphorylated S910 of human FAK
- The orthologous phosphorylation sites in mouse and rat FAK are S948 and S913, respectively
- Intracellular Staining
Compare Similar Items
Show Difference
Antigen: FAK (pS910)
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: K73-480
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human FAK Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
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Antigen:
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Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
K73-480
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
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Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
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Antigen: Rb (pS780)
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