CD49b Hamster anti-Mouse, PE, Clone: HMA2, BD

Description

• The HM α 2 antibody reacts with integrin α 2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the integrin β 1 subunit (CD29) to form the integrin α 2β 1 complex known as VLA-2
• VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets; but it is not on thymocytes or Peyer’s-patch or lymphnode lymphocytes
• The expression of VLA-2 is upregulated on lymphocytes in response to mitogens
• The HM α 2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen
• Purified HM α 2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat
• No
• 553858, for the PE conjugate)
• Therefore, mAb HM α 2 may be used like the DX5 mAb for identification of NK cells.