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BDB560164

PKA RIIα (pS99) Mouse anti-Human, Alexa Fluor 647, Clone: I65-856.286, BD

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB560164-Each-of-1 In Stock ₹ 25,154.64

BDB560164 - Each of 1

₹ 25,154.64

In Stock

Quantity

1

Base Price: ₹ 25,154.64

GST (18%): ₹ 4,527.835

Total Price: ₹ 29,682.475

Antigen

PKA RIIα (pS99)

Classification

Monoclonal

Conjugate

Alexa Fluor 647

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

I65-856.286

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Phosphorylated Human PKA RIIα Peptide

Quantity

50 Tests

Research Discipline

Cell Biology

Target Species

Human

Isotype

IgG1 κ

Description

  • cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R)
  • Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ
  • These subunits define type I and II PKAs
  • Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active
  • Type I and II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ)
  • Type II PKA can be distinguished by autophosphorylation of the R subunits, while type I PKA binds Mg/ATP with high affinity
  • The cAMP-dependent autophosphorylation of the human RIIα subunit occurs at Serine 99 (S99) (Entrez Protein Accession No.CAA33094)
  • Most cells express both type I and type II PKAs
  • Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominantly found in nervous and adipose tissues
  • In addition to their enzyme regulatory activity, the RIIα and RIIβ subunits determine the subcellular location of the holoenzymes via their interactions with specific intracellular anchoring proteins
  • The I65-856.286 antibody recognizes human PKA RIIα phosphorylated at S99
  • Host Species: Mouse Clone: I65-856.286 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human PKA RIIα Peptide Intracellular Staining

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Antigen:
PKA RIIα (pS99)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
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Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
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50 Tests
Research Discipline:
Cell Biology
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Human
Isotype:
IgG1 κ

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