p53 (acK382) Mouse anti-Human, Alexa Fluor 647, Clone: L82-51, BD

Description

• The p53 protein is critical to regulation of normal cell growth and proliferation and is a suppressor of tumor cell proliferation
• Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression
• Mutations and/or allelic loss of the p53 gene are associated with a wide variety of human tumors
• Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion
• p53 also binds to DNA in a sequence-specific manner via recognition of a 20-bp consensus-binding site
• This interaction stimulates the expression of genes downstream of the p53 binding site
• A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase
• Post-translational acetylation of p53 enhances its DNA-binding activity
• There are multiple factors that affect p53 acetylation, thereby modulating cellular proliferation and apoptosis
• The L82-51 monoclonal antibody recognizes acetylated lysine 382 (acK382) in the C-terminal region of p53
• Host Species: Mouse Clone: L82-51 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Human p53 acetylated Peptide Intracellular Staining