BDB560445
H2AX (pS139) Mouse, Alexa Fluor 488, Clone: N1-431, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB560445-Each-of-1 | In Stock | ₹ 44,362.86 |
BDB560445 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,362.86
GST (18%): ₹ 7,985.315
Total Price: ₹ 52,348.175
Antigen
H2AX (pS139)
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human H2AX Peptide
Quantity
100 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG1 κ
Applications
In vitro Assay
Clone
N1-431
Description
H2A.X; H2A/X; H2AFX; HIST5-2AX; gamma-H2AX; γ-H2AX; H2AX (pS140)
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- Histones are highly basic proteins that complex with DNA to form chromatin
- The H2AX histone (∽15kDa calculated molecular weight) is a member of the H2A histone family whose members are components of nucleosomal histone octamers
- Double-stranded breaks in DNA caused by replication errors, apoptosis, or other physiological processes (including, immunoglobulin and TCR gene recombinations) and DNA damage caused by ionizing radiation, UV light, or cytotoxic agents lead to phosphorylation of H2AX on serine 139
- H2AX (pS139) is also referred to as H2AX (pS140) when the N-terminal methionine that is normally excised during posttranslational processing is included in amino acid sequence numbering
- Kinases such as ataxia telangiectasia mutated (ATM) or ATM-Rad3-related (ATR) phosphorylate H2AX to induce its function
- Phosphorylated H2AX (also termed, γ-H2AX) functions to recruit and localize DNA repair proteins or cell cycle checkpoint factors to the DNA-damaged sites
- In this way, phosphorylated H2AX promotes DNA repair and maintains genomic stability and thus helps prevent oncogenic transformations
- Immunofluorescent staining and bioimaging analysis of cultured cells can be used to readily identify H2AX (pS139)-containing foci
- As such, H2AX (pS139) immunofluorescence localization serves as a biomarker for nuclear sites of DNA damage (e.g., double-stranded DNA breaks) in affected cells
- Host Species: Mouse Clone: N1-431 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human H2AX Peptide Bioimaging, Intracellular Staining
Compare Similar Items
Show Difference
Antigen: H2AX (pS139)
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human H2AX Peptide
Quantity: 100 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse
Isotype: IgG1 κ
Applications: In vitro Assay
Clone: N1-431
Description: H2A.X; H2A/X; H2AFX; HIST5-2AX; gamma-H2AX; γ-H2AX; H2AX (pS140)
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
H2AX (pS139)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human H2AX Peptide
Quantity:
100 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG1 κ
Applications:
In vitro Assay
Clone:
N1-431
Description:
H2A.X; H2A/X; H2AFX; HIST5-2AX; gamma-H2AX; γ-H2AX; H2AX (pS140)
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD27
Classification: Monoclonal
Conjugate: Violet Fluor 450 (V450)
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: Human T-CLL cells
Quantity: 120 Tests
Research Discipline: Immunology
Target Species: Human
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: M-T271
Description: __
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD27
Classification:
Monoclonal
Conjugate:
Violet Fluor 450 (V450)
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
Human T-CLL cells
Quantity:
120 Tests
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
M-T271
Description:
__
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD44
Classification: Monoclonal
Conjugate: Violet Fluor 450 (V450)
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
Quantity: 0.1 mg
Research Discipline: Immunology
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Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD44
Classification:
Monoclonal
Conjugate:
Violet Fluor 450 (V450)
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
Quantity:
0.1 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
IM7
Description:
Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD44
Classification: Monoclonal
Conjugate: Violet Fluor 450 (V450)
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M2
Quantity: 25 μg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: IM7
Description: Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD44
Classification:
Monoclonal
Conjugate:
Violet Fluor 450 (V450)
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M2
Quantity:
25 μg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
IM7
Description:
Pgp-1; Ly-24; H-CAM; HERMES; ECMR-III; Hyaluronate Receptor
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.