CD4 Mouse anti-Human, BUV395, Clone: SK3, BD

Description

• The SK3 monoclonal antibody specifically binds to CD4
• The CD4 antigen is a 55 kDa type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily
• It is expressed on T-helper/inducer lymphocytes and monocytes
• CD3+CD4+ T cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes
• CD4 is also expressed on 80% to 95% of normal thymocytes
• The CD4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (CD3-CD4+)
• CD4 serves as a T cell coreceptor for MHC class II antigen recognition and as a receptor for the human immunodeficiency virus (HIV)
• The SK3 antibody inhibits HIV binding to CD4+ cells
• The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument
• With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector
• BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.