HLA-DR, DP, DQ Mouse anti-Human, Brilliant Violet 421, Clone: Tu39, BD

Description

• The TU39 monoclonal antibody specifically recognizes human major histocompatibility (MHC) Class II HLA-DR, DP and most DQ antigens
• These antigens are encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6
• MHC Class II antigens are transmembrane heterodimeric glycoproteins composed of α chain (36 kDa) and β chain (27 kDa) subunits
• They are expressed primarily on antigen presenting cells which include dendritic cells, monocytes, macrophages, thymic epitheli al cells, and B cells
• They are also expressed on activated T cells
• This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4+ T lineage cells
• The TU39 antibody is reportedly useful for immunophenotyping as well as functional studies including the inhibition of mixed lymphocyte reactions and antibody-mediated complement fixation on target cells
• The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter)
• BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.