CD62L Mouse anti-Human, BB515, Clone: DREG-56, BD

Description

• The DREG-56 monoclonal antibody specifically binds to CD62L
• CD62L is a 76-95 kDa glycoprotein that is also referred to as L-selectin or LECAM-1
• CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells
• The DREG-56 antibody recognizes the same antigen as LAM-1, and specifically inhibits >90% of binding of human lymphocytes to high endothelial venules (HEV) in frozen sections of peripheral, but not mucosal lymphoid tissue
• It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV
• The antibody was conjugated to BD Horizon™ BB515 which was developed exclusively by BD Biosciences
• With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (eg, 530/30-nm filter)
• This dye provides a much brighter alternative to FITC with less spillover into the PE detector.