IFN-γ Mouse anti-Human, APC-R700, Clone: B27, BD

Description

• The B27 monoclonal antibody specifically binds to human interferon- γ(IFN- γ)
• IFN-γis a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ + T cells
• IFN- γexerts i ts biological effects through specific binding to the high-affinity IFN- γReceptor Complex comprised of IFN- γβ subunits
• In addition to its antiviral effects, IFN- γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils
• In addition, IFN- γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets
• Th ese influences can involve IFN- γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells t hemselves
• Human IFN-γis a 14- 18 kDa glycoprotein containing 143 amino acid residues
• B27 is a neutralizing antibody
• The use of B27 antibody for epitope mapping of human IFN- γhas been described
• The B27 antibody has been reported not to bind to denatured IFN- γ.