CD62L Mouse anti-Human, BB515, Clone: SK11, BD

Description

• The SK11 monoclonal antibody specifically binds to CD62L which is also known as, L-selectin, Leukocyte-endothelial cell adhesion molecule 1 (LECAM1/LECAM-1), Leukocyte adhesion molecule 1 (LAM1/LAM-1), Lymph node homing receptor (LNHR), Leu-8, or TQ1
• CD62L is an ∽80 kDa type I transmembrane glycoprotein that belongs to the Selectin/LECAM family
• CD62L is differentially expressed on T cells, B cells, monocytes, granulocytes, and a subset of NK cells
• The CD62L molecule is the human homolog of the mouse lymph node homing receptor, MEL-14
• CD62L plays a role in leucocyte binding to inflamed endothelium and extravasation, as well as mediating lymphocyte homing into peripheral lymphoid tissues through high endothelial postcapillary venules
• Soluble CD62L can result from the proteolytic cleavage of cell surface CD62L during cellular activation or inflammation
• The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences
• With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g
• 530/30-nm filter)
• This dye provides a much brighter alternative to FITC with less spillover into the PE detector.